Use of human amniotic epithelial cells in mouse models of bleomycin-induced lung fibrosis: A systematic review and meta-analysis

PloS One
Fang HeShuo Feng

Abstract

Idiopathic pulmonary fibrosis (IPF) urgently requires effective treatment. Bleomycin-induced lung injury models are characterized by initial inflammation and secondary fibrosis, consistent with the pathological features of IPF. Human amniotic epithelial cells (hAECs) exhibit good differentiation potential and paracrine activity and are thus ideal for cell-based clinical therapies. The therapeutic effects of hAECs on lung fibrosis are attributed to many factors. We performed a systematic review of preclinical studies investigating the treatment of pulmonary fibrosis with hAECs to provide suggestions for their clinical use. PubMed and EMBASE were searched for original studies describing hAEC therapy in animal bleomycin-induced pulmonary fibrosis models. After quality assessments, the number and species of experimental animals, bleomycin dose, hAEC source and dosage, time and route of administration of transplanted cells in animals, and time animals were euthanized in nine controlled preclinical studies were summarized. Ashcroft scores, lung collagen contents, inflammatory cells and cytokines were quantitatively and/or qualitatively analyzed in this review. Publication bias was also assessed. Each of the nine preclinical studies h...Continue Reading

References

Apr 1, 1988·Journal of Clinical Pathology·T AshcroftV Timbrell
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·François HuauxSem H Phan
Feb 17, 2007·Acta Pharmacologica Sinica·Li GuXin-Lun Tian
Oct 27, 2007·Antioxidants & Redox Signaling·Benjamin D BringardnerClay B Marsh
Nov 13, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bethany B Moore, Cory M Hogaboam
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vanessa MartinsClaudia F Benjamim
Jun 5, 2010·American Journal of Respiratory and Critical Care Medicine·Yuben MoodleyUrsula Manuelpillai
Jun 7, 2011·American Journal of Obstetrics and Gynecology·Patricia VosdoganesTimothy J M Moss
May 1, 2012·American Journal of Obstetrics and Gynecology·Ryan J HodgesEuan M Wallace
Oct 10, 2012·Cell Transplantation·Patricia VosdoganesRebecca Lim
Jan 10, 2013·Cellular Reprogramming·Kaixuan ZhouToshio Nikaido
Jul 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Rafael F GuilhermeClaudia F Benjamim
Mar 29, 2014·BMC Medical Research Methodology·Carlijn R HooijmansMiranda W Langendam
Sep 6, 2014·Stem Cell Research & Therapy·Courtney A McDonaldTimothy Jm Moss
Oct 24, 2015·Stem Cells Translational Medicine·Nadim Srour, Bernard Thébaud
Mar 11, 2017·Trends in Immunology·Leonardo M R FerreiraJack L Strominger
Apr 4, 2017·Stem Cells Translational Medicine·Jean L TanRebecca Lim
Jun 2, 2017·Nature·David Cyranoski
Jul 1, 2017·BMC Biology·Siamon Gordon, Annette Plüddemann

❮ Previous
Next ❯

Methods Mentioned

BETA
Cesarean section
bronchoalveolar lavage
hAECs
PCR

Software Mentioned

SYRCLE
Review Manager

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.