PMID: 7547080Jan 1, 1994Paper

Use of human leukocyte antigen-mismatched allogeneic lymphokine-activated killer cells and interleukin-2 in the adoptive immunotherapy of patients with malignancies

Biotherapy
Y KimotoT Taguchi

Abstract

Clinical effects and side effects were studied in the adoptive immunotherapy of patients bearing malignant diseases using human leukocyte antigen (HLA)-mismatched allogeneic lymphokine-activated killer (LAK) cells. Allogeneic LAK cells were induced from peripheral blood lymphocytes (PBL) of normal donors by means of initial stimulation with pokeweed mitogen (PWM). Six of 15 patients applied in the adoptive immunotherapy showed clinical effects such as partial or complete regression of pulmonary metastasis, pleural effusion and primary tumor. All pulmonary metastatic lesions were eliminated in one case by this adoptive immunotherapy combined with chemotherapy. Generally toxic effects were chillness, fever and general fatigue which were reversible, and no allergic side effects occurred even though allogeneic LAK cells were injected frequently except one patient who showed preshock like symptom accompanied with leukocytopenia and continuous hypotension immediately after infusion but was finally rescued. In the patients who received more than 10(11) of allogeneic LAK cells, anti-HLA class I antibodies appeared without any evidence of autoantibody. However, immunological side effects were never experienced after injection of allogen...Continue Reading

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Citations

Aug 15, 1998·International Journal of Food Microbiology·T Matsuzaki
Aug 28, 2001·Journal of Hematotherapy & Stem Cell Research·T TonnE Seifried
Mar 29, 2001·Journal of Hematotherapy & Stem Cell Research·H G Klingemann
Aug 1, 1997·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T MatsuzakiT Yokokura
Oct 12, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Reinhard MeierHeike Daldrup-Link

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