Use of human recombinant growth hormone and human recombinant insulin-like growth factor-I in patients with human immunodeficiency virus infection

Hormone Research
S Hirschfeld

Abstract

Infection with the human immunodeficiency virus (HIV) can lead to global alterations in metabolism as well as immunodeficiency. There is dysregulation of endocrine function in adults and children, the extent and magnitude correlating with disease progression. Some of the more prominent abnormalities occur in the thyroid, gonadal, and somatomedin axes. Clinical manifestations of these abnormalities are growth failure in children, which is one of the most sensitive indicators of disease progression, and a wasting syndrome in adults and children. Although there are case reports of growth hormone (GH) deficiency in HIV-infected children, most patients with growth failure have normal serum levels of GH and normal to low levels of insulin-like growth factor-I (IGF-I). Antiretrovial therapy can improve the growth rate in children for a period of time if there is a drop in viral titer, but as the viral load increases, the growth rate decreases again. Administration of GH or IGF-I to these patients can improve the growth rate and lean body mass, and in some patients improve immune function. Although studies on resting energy expenditure in HIV-infected patients have shown increases, these are not proportional to disease progression, but...Continue Reading

Citations

Feb 27, 1999·The Pediatric Infectious Disease Journal·D DreimaneM E Geffner
Apr 2, 2009·Journal of Endocrinological Investigation·E S MajaliwaF Chiarelli
Dec 22, 1999·Depression and Anxiety·A BystritskyT Vapnik
Oct 30, 1998·Endocrine Reviews·S JainM E Geffner
May 4, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S Chappel
Sep 18, 2008·Arquivos brasileiros de endocrinologia e metabologia·Angela Maria Spinola-CastroGil Guerra-Junior

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