Use of hyperspectral imaging to distinguish normal, precancerous, and cancerous cells

Cancer
Anwer M SiddiqiWilliam Johnson

Abstract

The objective of the current study was to test the hypothesis that the cytologic diagnosis of cancer cells can be enhanced by the technique of hyperspectral imaging (HSI). As a proof of principle, HSI was employed to obtain hyperspectrum from a normal human fibroblast, as well as its telomerase-immortalized and SV40-transformed derivatives. Novel algorithms were developed to differentiate among these cell models based on spectral and spatial differences. Using the same technique with modified algorithms, the authors were able to differentiate among normal and precancerous (low-grade [LG] and high-grade [HG]) cervical cells and squamous cell carcinoma (SCC) on liquid-based Papanicolaou (Pap) test slides. The specificity for identifying normal fibroblast cell type based on spatial and spectral algorithms was 74.2%. The sensitivity for identifying telomerase-immortalized and SV40-transformed cells was 100% and 90.3%, respectively. The system identified normal cervical cells with a specificity of 95.8%. With regard to LG precancerous cells and HG precancerous cells, the sensitivity was 66.7% and 93.5%, respectively. The sensitivity detected for SCC was 98.6%. HSI can be utilized in prescreening liquid-based Pap test slides to impro...Continue Reading

References

Nov 26, 1998·The Journal of Pathology·A J EinsteinJ Gil
Sep 3, 1999·The Journal of Biological Chemistry·J YangG S Herron
Mar 22, 2001·Cytometry·R A SchultzH R Garner
Apr 28, 2004·Investigative Ophthalmology & Visual Science·Bahram KhoobehiHiroyuki Kawano
Apr 6, 2006·Physics in Medicine and Biology·Guido ZavattiniSimon R Cherry
Apr 25, 2006·The Urologic Clinics of North America·Michael J ManyakErik S Storm
Jun 20, 2006·Annals of Biomedical Engineering·Matthew E MartinTuan Vo-Dinh
Aug 26, 2006·Cancer Biology & Therapy·David T DickerWafik S El-Deiry
Sep 14, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·A Thomas Harris
Oct 18, 2006·Journal of Lower Genital Tract Disease·D G FerrisM L Faupel

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Citations

Jul 28, 2013·Methods : a Companion to Methods in Enzymology·Charilaos MousoulisCorey P Neu
Sep 24, 2013·Molecular BioSystems·Bruno César Feltes, Diego Bonatto
Sep 8, 2011·Journal of Biomedical Optics·Fartash VasefiJeffrey Carson
Aug 17, 2012·Journal of Biomedical Optics·Hamed AkbariBaowei Fei
Aug 14, 2008·BMC Systems Biology·Armen R KherlopianAndrew F Laine
Mar 3, 2011·Journal of Biomedical Optics·Eivind L P LarsenLars O Svaasand
Jun 7, 2011·Journal of Biomedical Optics·Robert T KesterTomasz S Tkaczyk
Nov 11, 2015·Journal of Medical Systems·Berkan UralMustafa Necmi İlhan
Jan 6, 2011·Cancer Science·Hamed AkbariNaofumi Tanaka
Sep 17, 2013·Lasers in Surgery and Medicine·Noora Neittaanmäki-PerttuErna Snellman
Jul 25, 2009·International Journal of Cancer. Journal International Du Cancer·Marc ArbynPhilip E Castle
Apr 21, 2009·American Journal of Obstetrics and Gynecology·Dana M ChasePhilip J DiSaia
Oct 11, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Jing SongDong Zhang
Jul 13, 2016·Journal of Biophotonics·Martin HohmannH Albrecht
Oct 4, 2012·Applied Spectroscopy·Matjaž KosecBoštjan Likar
Jan 13, 2016·Journal of Biomedical Optics·Konstantin B YushkovAleksander Y Abrosimov
Dec 7, 2017·Journal of Biomechanical Engineering·Nishir MehtaManas Ranjan Gartia
May 22, 2010·Applied Optics·Ziga SpiclinBostjan Likar
Aug 6, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nishir MehtaManas Ranjan Gartia
Apr 5, 2017·The Review of Scientific Instruments·Hoong-Ta Lim, Vadakke Matham Murukeshan
Jan 1, 2019·Visual Computing for Industry, Biomedicine and Art·Ling MaBaowei Fei
Jan 1, 2021·Photodiagnosis and Photodynamic Therapy·Aziz Ul Rehman, Shahzad Ahmad Qureshi

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