Use of idarucizumab in reversing dabigatran anticoagulant effect: a critical appraisal

Therapeutics and Clinical Risk Management
Marco Proietti, Giuseppe Boriani

Abstract

Use of non-vitamin K antagonist oral anticoagulants is spreading in the real world. Despite that, a strong need for antidotes/reversal agents is still reported by several physicians. Idarucizumab is a humanized monoclonal antibody fragment that binds specifically to dabigatran. Idarucizumab was approved in 2015 by the US Food and Drugs Administration and European Medicines Agency for reversal of anticoagulation activity in dabigatrantreated patients. This review briefly summarizes the experimental evidence about effectiveness and safety of idarucizumab. Furthermore, we review the current recommendations and experts' point of view about the use of antidotes/reversal agents in patients reporting a major bleeding event.

Citations

Sep 13, 2019·Journal of Thrombosis and Thrombolysis·Rahul ChaudharyPaul Gurbel
Feb 25, 2021·European Journal of Preventive Cardiology·Giuseppe BorianiUNKNOWN Council of Cardio-Oncology of the European Society of Cardiology
Jun 19, 2021·Journal of the American College of Cardiology·Antonio Gómez-OutesEmilio Vargas-Castrillón

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