Use of implanted gold fiducial markers with MV-CBCT image-guided IMRT for pancreatic tumours

Journal of Medical Imaging and Radiation Oncology
M PackardA Kirichenko

Abstract

Visualisation of soft tissues such as pancreatic tumours by mega-voltage cone beam CT (MV-CBCT) is frequently difficult and daily localisation is often based on more easily seen adjacent bony anatomy. Fiducial markers implanted into pancreatic tumours serve as surrogates for tumour position and may more accurately represent absolute tumour position. Differences in daily shifts based on alignment to implanted fiducial markers vs. alignment to adjacent bony anatomy were compared. Gold fiducial markers were placed into the pancreatic tumour under endoscopic ultrasound (EUS) guidance in 12 patients. Patients subsequently received image-guided intensity-modulated radiation therapy (IG-IMRT). MV-CBCT was performed prior to each fraction and isocentre shifts were performed based on alignment to the fiducial markers. We retrospectively reviewed archived MV-CBCT datasets and calculated shift differences in the left-right (LR), superior-inferior (SI) and anterior-posterior (AP) axes relative to shifts based on alignment to adjacent bony anatomy. Two hundred forty-three fractions were analysed. The mean absolute difference in isocentre shifts between the fiducial markers and those aligned to bony anatomy was 3.4 mm (range 0-13 mm), 6.3 mm...Continue Reading

References

Jun 23, 2000·International Journal of Radiation Oncology, Biology, Physics·M van HerkJ V Lebesque
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Eugene HuangAlan Pollack
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Martin FussCharles R Thomas
Nov 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Priya JayachandranDaniel T Chang
Nov 22, 2011·International Journal of Radiation Oncology, Biology, Physics·Eric T ShinoharaJames M Metz
Apr 9, 2013·International Journal of Radiation Oncology, Biology, Physics·Michael D ChuongRavi Shridhar
Jun 25, 2013·International Journal of Radiation Oncology, Biology, Physics·Astrid van der HorstArjan Bel
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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Citations

Jan 25, 2017·Gastrointestinal Endoscopy·UNKNOWN ASGE Technology CommitteeSubhas Banerjee
May 31, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Sergej SchneiderAswin L Hoffmann
Apr 2, 2021·GE Portuguese Journal of Gastroenterology·Susana MarquesNuno Nunes

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