Use of inhaled heparin/N-acetylcystine in inhalation injury: does it help?

Journal of Burn Care & Research : Official Publication of the American Burn Association
Joshua HoltAmalia Cochran

Abstract

Inhaled heparin/N-acetylcystine (AHA) has been reported to decrease mortality in children with inhalation injury. The use of AHA therapy in adult burn patients with inhalation injury has not been evaluated. We hypothesized that patients who received AHA therapy in the management of inhalation injury would have better pulmonary mechanics and better clinical outcomes than patients who did not. This study is a retrospective chart review of pulmonary mechanics and clinical outcomes in all inpatients identified in the institutional ABA/TRACS database as having sustained inhalation injury from 1999 to 2005. Patients were not assigned to a treatment group. One hundred and fifty patients with inhalation injury were identified. Sixty-two patients were treated with AHA during the first 72 hours of admission. Treatment occurred mostly in patients admitted after 2002, with only 18 patients receiving AHA from 1999 through 2002. Treated and untreated patients did not differ in age or TBSA burn injury, nor did any studied clinical outcome differ between treated and untreated groups. In addition, there was no difference in pulmonary findings at 1 week after injury between treated and untreated patients. Although best Pao2 was higher in treated...Continue Reading

References

Oct 1, 1991·Journal of Applied Physiology·T IsagoD L Traber
Jan 1, 1989·The Journal of Burn Care & Rehabilitation·H A LinaresD L Traber
Jan 1, 1988·The Journal of Burn Care & Rehabilitation·M BrownD L Traber
Jul 1, 1987·Clinical Orthopaedics and Related Research·J H Herndon
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S CuzzocreaA P Caputi

❮ Previous
Next ❯

Citations

Mar 17, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·David J Dries
Oct 29, 2015·Critical Care : the Official Journal of the Critical Care Forum·Patrick F WalkerKevin K Chung
Aug 13, 2013·Journal of Critical Care·Noha M ElsharnoubyYasser A Aboelatta
Oct 18, 2015·Thrombosis Research·K MonagleF Newall
Dec 3, 2015·Paediatric Respiratory Reviews·Chong Tien Goh, Stephen Jacobe
Feb 9, 2016·Journal of Thrombosis and Haemostasis : JTH·G J GlasM J Schultz
Aug 18, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Allyson M McIntireTodd A Walroth
Jul 17, 2013·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Ana Carolina Peçanha AntonioLuiz Octavio Freire
Dec 18, 2009·Chemico-biological Interactions·Philip C BurchamColin A Thompson
Sep 8, 2012·Journal of Intensive Care Medicine·Adrian A Maung, Lewis J Kaplan
Jan 24, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·David J Dries
Apr 20, 2013·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·David J Dries, Frederick W Endorf
Feb 24, 2010·Wiener klinische Wochenschrift·Ulrich ThalerPhilipp G H Metnitz
Dec 14, 2018·The European Respiratory Journal·Arietta Spinou, Nikolaos G Koulouris
Apr 17, 2016·Annals of Intensive Care·Gerie J GlasMarcus J Schultz
Mar 21, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Ke-Yun ChaoChi-Wei Tseng
Mar 29, 2020·Journal of Clinical Medicine·Gerie J GlasMarcus J Schultz
Aug 27, 2009·Critical Care Medicine·Barbara A Latenser
Jul 1, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Courtney L CoxTodd A Walroth
Apr 24, 2015·Biomolecules·Mark RinnerthalerKlaus Richter
Jul 24, 2020·Critical Care : the Official Journal of the Critical Care Forum·Frank M P van HarenBarry Dixon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Burn Care & Rehabilitation
Rodger ShorttRobert Cartotto
Journal of Burn Care & Research : Official Publication of the American Burn Association
Itoro ElijahAmalia Cochran
Journal of Burn Care & Research : Official Publication of the American Burn Association
T PalmieriD G Greenhalgh
Burns : Journal of the International Society for Burn Injuries
Z HassanK W Dunn
© 2021 Meta ULC. All rights reserved