Use of Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy for Primary Hyperparathyroidism: A Systematic Review and Meta-analysis.

JAMA Otolaryngology-- Head & Neck Surgery
Alanna Jane QuinnAoife J Lowery

Abstract

Intraoperative parathyroid hormone (ioPTH) is a surgical adjunct that has been increasingly used during minimally invasive parathyroidectomy (MIP). Despite its growing popularity, to our knowledge a meta-analysis comparing MIP with ioPTH vs MIP without ioPTH has not yet been conducted. To evaluate the safety and efficacy of MIP with ioPTH for treatment of primary hyperparathyroidism. A systematic search of the databases PubMed, Embase, Scopus, Web of Science, and Cochrane Collaboration was performed to identify studies that compared MIP with and without ioPTH. Data were analyzed between August and September 2019. Inclusion criteria consisted of randomized clinical trials and observational studies with a retrospective/prospective design, comparing MIP using ioPTH vs MIP not using ioPTH for treatment of primary hyperparathyroidism. Eligible studies had to present odds ratio (OR), risk ratio, or hazard ratio estimates (with 95% CI), standard errors, or number of events necessary to calculate these for the outcome of interest rate. Studies involving patients with secondary or tertiary hyperparathyroidism or those with multiple endocrine neoplasia syndrome were excluded. Two reviewers independently reviewed the literature according ...Continue Reading

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Citations

Sep 3, 2021·JAMA Otolaryngology-- Head & Neck Surgery·Alanna J QuinnAoife J Lowery
Sep 3, 2021·JAMA Otolaryngology-- Head & Neck Surgery·Tam-Lin Chow
Mar 14, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Rodrigo CasanuevaJuan P Rodrigo

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