Use of intrathoracic pressure regulation therapy in breathing patients for the treatment of hypotension secondary to trauma

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Victor A ConvertinoCharles J Lick

Abstract

Intrathoracic pressure regulation (IPR) therapy has been shown to increase blood pressure in hypotensive patients. The potential value of this therapy in patients with hypotension secondary to trauma with bleeding is not well understood. We hypothesized that IPR would non-invasively and safely enhance blood pressure in spontaneously breathing patients with trauma-induced hypotension. This prospective observational cohort study assessed vital signs from hypotensive patients with a systolic blood pressure (SBP) ≤90 mmHg secondary to trauma treated with IPR (ResQGARD™, ZOLL Medical) by pre-hospital emergency medical personnel in three large US metropolitan areas. Upon determination of hypotension, facemask-based IPR was initiated as long as bleeding was controlled. Vital signs were recorded before, during, and after IPR. An increased SBP with IPR use was the primary study endpoint. Device tolerance and ease of use were also reported. A total of 54 patients with hypotension secondary to trauma were treated from 2009 to 2016. The mean ± SD SBP increased from 80.9 ± 12.2 mmHg to 106.6 ± 19.2 mmHg with IPR (p < 0.001) and mean arterial pressures (MAP) increased from 62.2 ± 10.5 mmHg to 81.9 ± 16.6 mmHg (p < 0.001). There were no signi...Continue Reading

References

Sep 29, 1998·The Journal of Trauma·S R HeckbertR V Maier
Jul 9, 2004·Critical Care Medicine·Keith G LurieWolfgang G Voelckel
May 18, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Caroline A RickardsVictor A Convertino
Mar 1, 2008·Journal of Applied Physiology·Kathy L RyanVictor A Convertino
Apr 8, 2010·Critical Care : the Official Journal of the Critical Care Forum·Rolf RossaintUNKNOWN Task Force for Advanced Bleeding Care in Trauma
Jul 17, 2010·The Journal of Emergency Medicine·Stephen W SmithJoseph Clinton
Feb 22, 2011·Respiratory Care·Victor A ConvertinoKeith G Lurie
Sep 29, 2012·The Journal of Trauma and Acute Care Surgery·Victor A ConvertinoDavid Lindstrom
Aug 1, 2015·Military Medicine·Andrew D FisherShawn F Kane

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Citations

Jun 22, 2019·Journal of Applied Physiology·Victor A Convertino

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