Use of intravenous immune globulin and rituximab for desensitization of highly HLA-sensitized patients awaiting kidney transplantation

Transplantation
A VoS C Jordan

Abstract

BACKGROUND.: We have shown that high-dose intravenous immune globulin (IVIG; 2 g/kg x2 doses)+rituximab (1 g x2 doses) was effective in lowering anti-human leukocyte antigen (HLA) antibodies and improving rates of transplantation. The aim of this report was to evaluate the efficacy of IVIG+rituximab on reduction of anti-HLA antibodies to a level that was permissive for living donor (LD) or deceased donor (DD) transplantation without incurring the risk of antibody-mediated rejection and immediate graft loss. METHODS.: From July 2006 to February 2009, 76 HLA-sensitized (HS) patients who met strict sensitization criteria received kidney transplants after desensitization using IVIG 2 g/kg (days 1 and 30)+rituximab (1 g, day 15). Parameters evaluated included rates of transplantation, previous transplants, panel reactive antibodies, donor specific antibody, crossmatches (CMXs), patient and graft survival, acute rejection, serum creatinines, and infections. RESULTS.: Seventy-six HS CMX treated patients (31 LD/45 DD) were transplanted. For LD and DD recipients, significant reductions were seen in T-cell flow cytometry CMXs from pretreatment (T cell 183.5+/-98.4 mean channel shifts (MCS) for LD and 162.8+/-41 MCS for DD) to time of tra...Continue Reading

References

Oct 1, 1992·Transplantation·J D RussellD N Churchill
Feb 28, 1985·The New England Journal of Medicine·R W EvansE G Lowrie
Sep 15, 1993·JAMA : the Journal of the American Medical Association·F K PortK Jiang
Nov 25, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Howard M GebelPeter Nickerson
Dec 20, 2003·Transplant International : Official Journal of the European Society for Organ Transplantation·Denis GlotzJean Bariety
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
May 25, 2005·Pediatric Transplantation·Stanley C JordanMieko Toyoda
Jul 26, 2005·Transplantation·Mieko ToyodaStanley C Jordan
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S C JordanD Tyan
Apr 20, 2006·Nature Reviews. Immunology·Jonathan C W Edwards, Geraldine Cambridge
Jul 28, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A A VoS C Jordan
Aug 26, 2006·Nature Clinical Practice. Nephrology·Alan D Salama, Charles D Pusey
Oct 27, 2006·The New England Journal of Medicine·A Razzaque AhmedMarshall R Posner
Mar 14, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezJ J Weening
May 15, 2007·Transplantation·Stanislas FaguerLionel Rostaing
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Stanley C Jordan, Mark D Pescovitz
Mar 14, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Stamatis-Nick C Liossis, Petros P Sfikakis
Mar 29, 2008·Annual Review of Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Jul 19, 2008·The New England Journal of Medicine·Ashley A VoStanley C Jordan
Jul 9, 2009·Transplantation·Stanley C JordanAshley A Vo

❮ Previous
Next ❯

Citations

Jul 3, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Caitlin E Carter, Nadine M Benador
Dec 15, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Sanjeev BawejaLawrence P McMahon
Apr 25, 2012·International Urology and Nephrology·Kyu Ha HuhJin Min Kong
Aug 26, 2010·Nature Reviews. Nephrology·Inés Rama, Josep M Grinyó
Apr 18, 2012·Nature Reviews. Nephrology·Alexandre LoupyStanley C Jordan
Sep 18, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudio PonticelliMaurizio Salvadori
Sep 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN European Renal Best Practice Transplantation Guideline Development Group
Aug 22, 2012·QJM : Monthly Journal of the Association of Physicians·A SharifE Kraus
Aug 20, 2010·Current Opinion in Nephrology and Hypertension·Howard M Gebel, Robert A Bray
Mar 21, 2013·Transplantation·Ashley A VoStanley C Jordan
Mar 20, 2013·Transplantation·Stanley C JordanNancy Reinsmoen
Mar 20, 2013·Transplantation·Kwaku Marfo, Enver Akalin
Oct 19, 2010·Journal of Transplantation·Rajeev RaghavanAbdul Abdellatif
Dec 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Joseph KahwajiAshley Vo
Jul 15, 2011·Immunotherapy·Martijn W F van den Hoogen, Luuk B Hilbrands
Sep 24, 2013·Transplantation·Mark D StegallPatrick G Dean
Aug 7, 2010·Current Opinion in Organ Transplantation·Peter M Eckman
Oct 12, 2010·Current Opinion in Organ Transplantation·Renaud SnanoudjChristophe Legendre
Dec 15, 2010·Current Opinion in Organ Transplantation·Jeffrey L PlattMarilia Cascalho
Jun 15, 2011·Current Opinion in Organ Transplantation·Stanley C JordanAshley Vo
Jun 15, 2011·Current Opinion in Organ Transplantation·Keri E LunsfordTodd V Brennan
Oct 6, 2011·Current Opinion in Organ Transplantation·Georg A BöhmigGregor Bartel
Jun 20, 2012·Current Opinion in Organ Transplantation·Annette M JacksonAndrea A Zachary
Oct 9, 2014·Immunological Investigations·Oleh PankewyczMark R Laftavi
Feb 3, 2011·Expert Opinion on Pharmacotherapy·Marcia KhoTeun van Gelder
Apr 6, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Deborah J LevineAdriana Zeevi
Jan 19, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A MujtabaT E Taber
Nov 21, 2012·Transplant Immunology·Tariq ShahDavid I Min
Apr 3, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stanley C Jordan, Ashley A Vo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.