PMID: 8613492Nov 1, 1995Paper

Use of intravenous immune globulin in the therapy of children with rheumatological diseases

Journal of Clinical Immunology
C M Roifman

Abstract

Traditional treatment of dermatomyositis often fails and is associated with severe side effects, especially in children. Similarly, some patients with systemic juvenile rheumatoid arthritis continue to develop crippling arthritis despite the currently used modalities of therapy. We have used monthly infusions of intravenous immune globulin (2 g/kg/month) in patients with dermatomyositis or systemic juvenile rheumatoid arthritis who have not responded to traditional treatment. We show that intravenous immune globulin is beneficial in improving muscle strength and skin manifestations of dermatomyositis. In a similar fashion, intravenous immune globulin infusions were very effective in ameliorating systemic manifestations of systemic juvenile rheumatoid arthritis but less effective in controlling long-lasting arthritis (more than 1 year). We established prognostic criteria early after disease onset which predict the development of severe joint disease and should help in patient selection for future studies.

References

Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Jul 1, 1990·Arthritis and Rheumatism·E D SilvermanC M Roifman
Aug 1, 1991·The American Journal of Medicine·B A LangC M Roifman
Feb 1, 1992·The Journal of Pediatrics·R SchneiderC M Roifman
Aug 7, 1986·The New England Journal of Medicine·J W NewburgerS P Sanders
Jul 24, 1987·JAMA : the Journal of the American Medical Association·C M RoifmanE W Gelfand

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Citations

Feb 6, 2002·Springer Seminars in Immunopathology·L RauovaY Shoenfeld
Oct 23, 2009·The Journal of Pediatrics·Deborah M LevyLisa F Imundo
Oct 17, 2002·Rheumatic Diseases Clinics of North America·Diana S Milojevic, Norman T Ilowite
Jun 24, 2004·Expert Opinion on Pharmacotherapy·C S ZipitisA V Ramanan
Aug 1, 1997·Rheumatic Diseases Clinics of North America·L G Rider, F W Miller
Sep 6, 2000·International Journal of Dermatology·D MimouniO Shpilberg

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