Use of intravenous immunoglobulin compared with standard therapy is associated with improved clinical outcomes in children with acute encephalitis syndrome complicated by myocarditis.

Pediatric Cardiology
Girish Chandra BhattK P Kushwaha

Abstract

Although an autoimmune mechanism has been postulated for acute encephalitis syndrome (AES) complicated by myocarditis, immunomodulatory treatment strategies are still under investigation. To study the role of intravenous immunoglobulin (IVIG) in AES complicated by myocarditis in children age 2-12 years. This nonrandomized study was conducted in a tertiary care teaching hospital from July 2008 to January 2010. A total of 83 consecutive children with AES complicated by myocarditis were enrolled. Diagnosis of myocarditis was based on clinical, electrocardiogram, and echocardiogram findings. Patients were allocated to the two groups based on the days of the week: Those presenting on Monday and Friday were allocated to IVIG treatment (group I), and those presenting on the other days of the week to standard care (group II). Group I (n = 26) patients received IVIG at a dose of 400 mg/kg/day for 5 days in addition to standard care. All baseline and outcome data were recorded prospectively in a prestructured performa. The primary outcomes were mortality and improvement of left-ventricular dysfunction. A total of 83 children were studied: 26 in group I and 57 in group II. The mean (SD) age of the enrolled children was 4.6 years (3.1). Th...Continue Reading

References

Dec 1, 1991·Journal of the American College of Cardiology·E B LiebermanK L Baughman
Jan 1, 1994·Circulation·N A DruckerJ W Newburger
Dec 10, 1999·Journal of the American College of Cardiology·S G PophalS C Park
Feb 27, 2001·Current Opinion in Cardiology·D Levi, J Alejos
Apr 9, 2002·Pediatric Hematology and Oncology·Mary MoschoviMaria A Moscjovi
Dec 3, 2002·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Fiorella CalabreseGaetano Thiene
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tzou-Yien LinLuan-Yin Chang
Jun 26, 2003·The Journal of Infectious Diseases·Amy Guillet Agrawal, Lyle R Petersen
Apr 9, 2004·The Pediatric Infectious Disease Journal·Luan-Yin ChangTzou-Yien Lin
Aug 11, 2004·International Journal of Cardiology·Hae Soon KimJeong Wan Seo
Jan 28, 2005·The Cochrane Database of Systematic Reviews·J RobinsonT P Klassen
Feb 1, 2005·Cardiology in the Young·Robert F EnglishSteven A Webber
May 4, 2005·Human Immunology·Feng Jin, Joseph P Balthasar
Feb 2, 2006·Heart·N AmabileC Ovaert
Jul 25, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Shih-Min WangChing-Chuan Liu
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mong How OoiTom Solomon
Jan 15, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Luigi Brunetti, Evelyn R Hermes DeSantis
Jan 29, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Farzana K BeigShashi Khare
Mar 30, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Arvind KumarTapan N Dhole

❮ Previous
Next ❯

Citations

May 24, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anne-Laure Sellier-LeclercGeorges Deschênes
Apr 12, 2014·Current Heart Failure Reports·Bernhard MaischSabine Pankuweit
Dec 10, 2015·Expert Review of Cardiovascular Therapy·Paul F KantorSteven E Lipshultz
Oct 28, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroyuki MatsuuraSatoshi Yasukochi
Oct 3, 2017·The Cochrane Database of Systematic Reviews·Mildred A IroAndrew J Pollard
Sep 2, 2014·Pathogens and Global Health·Shikha JainGirish Chandra Bhatt
Aug 23, 2019·Congenital Heart Disease·Soham DasguptaMatthew E Oster
Aug 25, 2020·The Cochrane Database of Systematic Reviews·Joan RobinsonTerry P Klassen
May 21, 2015·The Cochrane Database of Systematic Reviews·Joan RobinsonTerry P Klassen
Feb 13, 2019·International Heart Journal·Xin HuangXinxin Shuai
Aug 12, 2017·Cardiology in the Young·Josephine F HeidendaelDasja Pajkrt
Dec 3, 2016·Developmental Medicine and Child Neurology·Jonathan GadianMichael Absoud
Jul 24, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Soham Dasgupta
Jul 8, 2021·Circulation·Yuk M LawUNKNOWN American Heart Association Pediatric Heart Failure and Transplantation Committee of the Council on Lifelong Congenital Heart

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Hemorrhagic Leukoencephalitis

Acute hemorrhagic leukoencephalitis is a rare form of acute disseminated encephalomyelitis characterized by acute inflammation in the brain and spinal cord that causes demyelination and bleeding. It is often fatal, although treatment with immunosuppressives and plasma exchange can be helpful. Find the latest research on acute hemorrhagic leukoencephalitis here.