Use of intravenous immunoglobulin in toxic epidermal necrolysis and Stevens-Johnson syndrome: our current understanding

International Immunopharmacology
Lars E FrenchFrancisco A Kerdel

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN, Lyell's disease, syndrome) are considered to be part of a spectrum of adverse cutaneous drug reactions with increasing severity and extent of skin detachment, ranging from SJS (less than 10% body surface area skin detachment, 1-5% mortality) to TEN (greater than 30% skin detachment, 25-35% mortality). Both SJS and TEN are characterized morphologically by ongoing apoptotic keratinocyte cell death that results in the separation of the epidermis from the dermis. Recent evidence is supportive of a role for the death receptor Fas and its ligand FasL, in the pathogenesis of keratinocyte apoptosis during TEN. This Fas-mediated keratinocyte apoptosis that causes epidermal detachment in TEN can be inhibited in vitro by antagonistic monoclonal antibodies to Fas and by intravenous immunoglobulins (IVIG) which have been shown to contain natural anti-Fas antibodies. Over the last 6 years, numerous case reports and 8 non-controlled clinical studies containing 9 or more patients have analyzed the therapeutic effect of IVIG in TEN. Taken together, although each study has its potential biases, 6 of the 8 studies point towards a benefit of IVIG used at doses greater than 2 g/kg ...Continue Reading

References

Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Apr 1, 1996·The British Journal of Dermatology·C PaulJ C Roujeau
Aug 22, 2000·The Journal of Investigative Dermatology·S Bastuji-GarinP Wolkenstein
Sep 11, 2001·Dermatology : International Journal for Clinical and Investigative Dermatology·M StellaG Giorio
Jan 21, 2003·Archives of Dermatology·Christa PrinsUNKNOWN TEN-IVIG Study Group. Toxic epidermal necrolysis-intravenous immunoglobulin
Jul 2, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Christa PrinsLars E French
Jan 17, 2004·The Journal of Burn Care & Rehabilitation·K M BrownRichard L Gamelli
Jul 27, 2004·The Journal of Burn Care & Rehabilitation·Rodger ShorttRobert Cartotto

❮ Previous
Next ❯

Citations

Jun 6, 2007·Current Allergy and Asthma Reports·Steven J Parrillo
May 21, 1998·Lancet·D S Becker
May 21, 2010·Mucosal Immunology·M E SternS C Pflugfelder
Apr 2, 2014·Burns : Journal of the International Society for Burn Injuries·Patrick D MaharAnneliese B Spinks
Jul 23, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sheena N RamasamyRichard O Day
Nov 18, 2015·Immunological Investigations·Barbara E Ostrov
Apr 23, 2013·Emergency Medicine Clinics of North America·Alisa M Gibson, Sarah K Sommerkamp
Dec 16, 2011·Journal of the American Academy of Dermatology·Andrew DowneyAlan Cooper
Jan 11, 2011·Medicina intensiva·A Fernández CarmonaJ L Ballesteros Martínez
Dec 17, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Yumiko YamaneMichiko Aihara
Oct 9, 2009·Journal of the American Academy of Dermatology·Mark Jean-Aan Koh, Yong-Kwang Tay
Sep 22, 2009·Burns : Journal of the International Society for Burn Injuries·Mario LissiaCorrado Rubino
Jul 14, 2006·Mayo Clinic Proceedings·Gautam KumarThomas J Beckman
Apr 14, 2007·Dermatologic Clinics·Sandra R Knowles, Neil H Shear
Dec 19, 2006·Seminars in Cutaneous Medicine and Surgery·Mary Jo J KernsMichael P Heffernan
May 25, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·X LiL Sun
Mar 29, 2014·International Journal of Dermatology·Sasmita Biswal, Swayam Sourav Sahoo
Jul 14, 2010·ANZ Journal of Surgery·Nathan M Harris, Richard B Wong She
Jun 12, 2010·The Journal of Dermatology·Hiroomi HosakaMasafumi Iijima
Aug 25, 2006·The Annals of Thoracic Surgery·Hendrik Jan AnkersmitErnst Wolner
Jul 11, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·G MionJ-L Daban
Aug 16, 2006·Seminars in Cutaneous Medicine and Surgery·Jennifer TrentFrancisco Kerdel
Jun 15, 2014·Journal of the American Academy of Dermatology·Andrea ParadisiBiagio Didona
Mar 7, 2014·Medical Journal, Armed Forces India·Rajesh VermaVijendran Pragasam
Aug 24, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Yumiko YamaneZenro Ikezawa
Jun 23, 2016·Journal of Pharmaceutical Health Care and Sciences·Junko AbeMitsuhiro Nakamura
Jul 13, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Yuri Kinoshita, Hidehisa Saeki
Apr 19, 2007·The Annals of Pharmacotherapy·Hakan M Gürcan, A Razzaque Ahmed
Jul 21, 2017·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yuri Kinoshita, Hidehisa Saeki
Sep 3, 2011·Journal of Intensive Care Medicine·Eng-Kean YeongWu M Z
Sep 12, 2007·Pediatric Dermatology·Arzu BabayigitOzkan Karaman
May 29, 2009·Current Opinion in Pediatrics·Mark Jean-Aan Koh, Yong-Kwang Tay
Apr 8, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Sunali GoyalRobert L Sheridan
Feb 18, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Philippe Paquet, Gérald E Piérard
Mar 3, 2019·International Journal of Dermatology·Amy J ZhangSara A Hylwa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

The Journal of Burn Care & Rehabilitation
K M BrownRichard L Gamelli
Journal of Burn Care & Research : Official Publication of the American Burn Association
Frederick W EndorfNicole S Gibran
© 2021 Meta ULC. All rights reserved