PMID: 9661122Jul 14, 1998Paper

Use of intravenous lipids in critically ill patients with sepsis without and with hepatic failure

JPEN. Journal of Parenteral and Enteral Nutrition
W DrumlK Ratheiser

Abstract

Fat is the preferred energy fuel both in patients with sepsis and with hepatic failure. Thus lipid emulsions should serve as an ideal nutritional substrate in parenteral nutrition. However, previous studies have generated conflicting results on the utilization of artificial lipids in these disease states, and systematic studies in critically ill patients with combined organ dysfunctions and additional complications are lacking. We compared the elimination, hydrolysis, and oxidation of a 20% lipid emulsion in critically ill patients on respiratory support with sepsis and with sepsis plus hepatic failure and in healthy control subjects. Medical critical care unit of a university hospital. Eight critically ill patients with sepsis, 8 patients with sepsis and decompensated chronic hepatic failure, and 10 healthy volunteers were investigated. Elimination and hydrolysis was evaluated during constant i.v. infusion of 4.5 mg.kg body wt-1.min-1 of triglycerides during 120 minutes. Concentrations of plasma triglycerides, free fatty acids, and glycerol were measured, and elimination parameters were analyzed from plasma curves of triglycerides by using a two-compartment model. Resting energy expenditure and substrate oxidation were measure...Continue Reading

References

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Citations

May 18, 2013·Medizinische Klinik, Intensivmedizin und Notfallmedizin·M Plauth
Feb 19, 1999·Journal of the American College of Surgeons·P O Hasselgren
Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·C Weissman
Jan 28, 2004·Wiener klinische Wochenschrift·Wilfred Druml, Margot Fischer
Sep 22, 2007·Critical Care Medicine·Luc Tappy, René Chioléro
May 17, 2012·Journal of the American Geriatrics Society·Jinling MaYuanyu Qian
Nov 16, 2006·European Journal of Clinical Nutrition·A B AliM M Reeves
Apr 30, 2003·Journal of Pediatric Gastroenterology and Nutrition·Robert J Shulman, Sarah Phillips
May 1, 2001·Current Opinion in Critical Care·Gérard Nitenberg
Apr 13, 2004·Current Opinion in Critical Care·Otto ClemmesenFin Stolze Larsen
Aug 18, 2000·Nutrition Reviews·S D LiA Hagerty
Oct 31, 2001·The American Journal of Clinical Nutrition·J A Coss-BuL S Jefferson

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