Use of iodine-123 as a diagnostic tracer for neck and whole-body scanning in patients with well-differentiated thyroid cancer.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
R BerbanoI Young

Abstract

To determine whether 123 I can be used as a safe and effective alternative tracer to 131 I for imaging remnant tissue and for searching for metastatic lesions of well-differentiated thyroid cancer. We studied a series of 16 patients (10 women and 6 men; 29 to 73 years of age) who had well-differentiated thyroid cancer and had undergone thyroidectomy and subsequent radioiodine treatment. Diagnostic 10 mCi (either preablation or postablation) were compared with the 5- to 7-day 131 I posttherapy scans (doses, 75 to 200 mCi). Scans were jointly interpreted by nuclear medicine and endocrinology staff members. Of the 16 patients, 15 had concordant findings between the 123 I diagnostic images and the corresponding 131 I posttherapy scans. Only one patient had additional lesions noted on the posttherapy 131 I scan, which was attributed to the higher dose the patient received during radioiodine treatment (a 6% discordance rate). This discordance, however, would not have changed the patient treatment. No advantage was noted for delayed imaging at 48 hours; the 24-hour images were satisfactory. The 123 I scans were of higher resolution than the 131 I scans. Diagnostic 123 I scans are an acceptable alternative to 131 I scanning for whole-b...Continue Reading

References

Jun 1, 1992·Clinical Nuclear Medicine·H M Park
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·H M ParkA Manatunga
Apr 1, 1997·Thyroid : Official Journal of the American Thyroid Association·H M ParkX H Zhou

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Citations

Mar 5, 2003·European Journal of Nuclear Medicine and Molecular Imaging·K E BrittonS L Chew
Jul 11, 2001·Endocrinology and Metabolism Clinics of North America·B R Haugen, E C Lin
Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Jason B CohenI Ross McDougall
Apr 14, 2005·Clinical Nuclear Medicine·Herbert A KleinLois J Worthy
Nov 29, 2011·Seminars in Nuclear Medicine·Charles M IntenzoSung M Kim
Sep 10, 2005·Seminars in Nuclear Medicine·Charles M IntenzoDavid M Capuzzi
May 25, 2002·Nuclear Medicine Communications·J E Kalinyak
Aug 11, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·G H Daniels
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·H M Abdel-Dayem, I Young

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