Use of iron chelators in preventing hydroxyl radical damage: adult respiratory distress syndrome as an experimental model for the pathophysiology and treatment of oxygen-radical-mediated tissue damage

Acta Haematologica
Joannes J M Marx, B S van Asbeck

Abstract

Tissue damage in many diseases is caused by hydroxyl radicals, generated during single electron reduction of oxygen. The first step is usually the formation of the superoxide radical. This radical is constantly formed in all living cells, and in particular during activation of phagocytes or during reoxygenation following ischaemia. Damage, however, only occurs in the presence of catalytic transition metals of which iron is the most important in human pathology. Oxygen-radical-mediated damage can be prevented by iron chelators, as has been demonstrated in numerous in vitro and in vivo experiments. A description is given as to how toxic oxygen products are formed in biological systems, and how organisms succeed in preventing autodestruction by scavenger molecules. The use of iron chelators to prevent oxygen radical damage is reviewed with emphasis on possible clinical applications. The adult respiratory distress syndrome is described in more detail as a model for oxygen-radical-mediated damage that can be successfully prevented with iron chelators.

Citations

Apr 30, 2002·Free Radical Biology & Medicine·Leona L GreenwellRoy J Richards
Jul 30, 2014·Hematology/oncology Clinics of North America·John B Porter, Maciej Garbowski
Mar 12, 2002·European Journal of Clinical Investigation·M P KooistraJ J M Marx
May 14, 1999·Arthritis and Rheumatism·G RoosendaalJ W Bijlsma
Oct 16, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Apriliana E R KartikasariJoannes J M Marx
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Funmei YangAndrew J Ghio
May 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Freddy J TroostRobert-Jan M Brummer
Dec 22, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Apriliana E R KartikasariJoannes J M Marx
Dec 22, 1999·The American Journal of Physiology·F YangA J Ghio
Apr 5, 2018·Clinical Hemorheology and Microcirculation·Eduard J van Beers, Richard van Wijk
Dec 18, 2020·Free Radical Research·Mahesh SubramanianSubrata Chattopadhyay
Nov 17, 2020·Frontiers in Medicine·Yuliya BuinitskayaSiarhei Kastsiuchenka

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