Use of ketofol for procedural sedation and analgesia in children with hematological diseases

Pediatrics International : Official Journal of the Japan Pediatric Society
Paulo Sérgio Lucas da SilvaMiriam Verônica Flor Park

Abstract

The aim of this study was to evaluate the effectiveness and safety of intravenous ketamine-propofol admixture ("ketofol") in the same syringe for procedural sedation and analgesia in children undergoing bone marrow aspiration. This was a prospective, observational pilot study. Patients aged between 4 and 12 years requiring sedation for bone marrow aspiration were included. Ketofol (1:1 mixture of ketamine 10 mg/mL and propofol 10 mg/mL) was given intravenously in 0.5 mg/kg aliquots each with a 1-min interval and titrated to reach sedation levels of 3 or 4 (Ramsay score). The primary outcome was patient satisfaction with the degree of sedation. Secondary outcomes included injection pain, total sedation time, recovery time, hemodynamic and respiratory parameters, and adverse events. A total of 20 patients were enrolled in the study. The median total dose of ketofol administered was 1.25 mg/kg each of propofol and ketamine (95%CI 0.77-2 mg/kg). The median score on the visual analog scale was 0 (extremely comfortable) (0-1.5; 95%CI 0.2-2.2). Median recovery time was 23 min (20.5-28 min; 95%CI 17.1-51.2). The incidence of injection pain was 2/20. Two patients had transient diplopia and one child reported dreams. No patients had hypo...Continue Reading

References

Jun 22, 1974·British Medical Journal·M A RamsayR Goodwin
Jun 1, 1997·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·L A TrisselJ F Martinez
Jul 11, 1998·Anaesthesia·C H Tan, M K Onsiong
Mar 29, 2000·Anesthesia and Analgesia·S BadrinathA D Ivankovich
Sep 6, 2000·Journal of Cardiothoracic and Vascular Anesthesia·C A BoteroA C Pinchak
Jul 31, 2001·Emergency Medicine·S J PriestleyP Francis
Apr 20, 2002·Anesthesiology·UNKNOWN American Society of Anesthesiologists Task Force on Sedation and Analgesia by Non-Anesthesiologists
May 23, 2002·Annals of Emergency Medicine·David R Vinson, David R Bradbury
Jan 9, 2003·Best Practice & Research. Clinical Anaesthesiology·Frederic Camu, Caroline Vanlersberghe
Nov 12, 2003·Archives of Pediatrics & Adolescent Medicine·Egidio BarbiAlessandro Ventura
Nov 18, 2003·Paediatric Anaesthesia·E BarbiA Ventura
Nov 25, 2003·Annals of Emergency Medicine·Kathlene E BassettElisabeth Guenther
Dec 23, 2003·Journal of Cardiothoracic and Vascular Anesthesia·Alexander KoganBernardo A Vidne
Jan 29, 2005·Paediatric Anaesthesia·Dan EvansPaul Rogers
May 26, 2005·The American Journal of Emergency Medicine·Joel S HolgerStephanie Haugen
Jun 7, 2005·International Journal of Pediatric Otorhinolaryngology·Aynur AkinAdem Boyaci
Mar 16, 2007·Paediatric Anaesthesia·Paulo Sérgio Lucas da SilvaWerther Brunow de Carvalho
Dec 20, 2007·Pediatric Emergency Care·Ghazala Q SharieffJim R Harley
Jan 24, 2008·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Corinne Michèle HohlAslam Hayat Anis
Aug 30, 2008·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·David W MessengerMarco L A Sivilotti
Mar 11, 2009·Pediatric Pulmonology·Rashed A Hasan, Ramalinga Reddy
Apr 22, 2009·AJR. American Journal of Roentgenology·Keira P MasonDavid Zurakowski
Aug 4, 2009·Paediatric Anaesthesia·Michael D MalloryUNKNOWN Pediatric Sedation Research Consortium
Apr 8, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Gary Andolfatto, Elaine Willman

❮ Previous
Next ❯

Citations

Dec 20, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Joseph E Cillo
Jun 4, 2014·Veterinary Anaesthesia and Analgesia·Fernando Martinez-Taboada, Elizabeth A Leece
Sep 14, 2015·Revista brasileira de anestesiologia·Handan GulecOsman Ozdemir
Sep 2, 2015·Brazilian Journal of Anesthesiology·Handan GulecOsman Ozdemir
Dec 3, 2017·Wiener medizinische Wochenschrift·Harald SauerJuergen Foell
Dec 12, 2012·Pediatric Emergency Care·Michelle J AlletagCarl R Baum
Mar 8, 2014·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Mohammad Reza HabibiAmir Emami Zeydi
Mar 16, 2012·Anaesthesia and Intensive Care·G Erdogan KayhanM O Ersoy
Aug 28, 2014·Pediatric Emergency Care·Finn L S CoulterBrian J Anderson
Jun 27, 2012·Current Opinion in Anaesthesiology·Jeana E Havidich, Joseph P Cravero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.