PMID: 19149590Jan 20, 2009Paper

Use of lactobacilli and their pheromone-based regulatory mechanism in gene expression and drug delivery

Current Pharmaceutical Biotechnology
D B DiepI F Nes

Abstract

Lactobacilli are common microorganisms in diverse vegetables and meat products and several of these are also indigenous inhabitants in the gastro-intestinal (GI) tract of humans and animals where they are believed to have health promoting effects on the host. One of the highly appreciated probiotic effects is their ability to inhibit the growth of pathogens by producing antimicrobial peptides, so-called bacteriocins. Production of some bacteriocins has been shown to be strictly regulated through a quorum-sensing based mechanism mediated by a secreted peptide-pheromone (also called induction peptide; IP), a membrane-located sensor (histidine protein kinase; HPK) and a cytoplasmic response regulator (RR). The interaction between an IP and its sensor, which is highly specific, leads to activation of the cognate RR which in turn binds to regulated promoters and activates gene expression. The HPKs and RRs are built up by conserved modules, and the signalling between them within a network is efficient and directional, and can easily be activated by exogenously added synthetic IPs. Consequently, components from such regulatory networks have successfully been exploited in construction of a number of inducible gene expression systems. I...Continue Reading

Citations

Aug 23, 2011·Biotechnology Journal·Clemens PeterbauerDietmar Haltrich
Sep 21, 2010·Applied and Environmental Microbiology·Lasse FredriksenVincent G H Eijsink
Mar 13, 2014·PloS One·Ingrid Lea KarlskåsGeir Mathiesen
Sep 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mduduzi Paul Mokoena
Feb 19, 2013·FEMS Microbiology Letters·Nico BöhmerLutz Fischer
May 14, 2016·Microbial Cell Factories·Suttipong Sak-UbolMontarop Yamabhai
Jul 29, 2010·The Journal of Antibiotics·Sergio SánchezBeatriz Ruiz
Jun 19, 2012·Applied and Environmental Microbiology·Lasse FredriksenGeir Mathiesen
Jun 5, 2014·ACS Synthetic Biology·Juan BorreroYiannis N Kaznessis
Apr 21, 2011·Journal of Agricultural and Food Chemistry·Tien-Thanh NguyenClemens K Peterbauer
Aug 28, 2021·Trends in Microbiology·Ronit SuissaIlana Kolodkin-Gal

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