PMID: 9429127Jan 16, 1998Paper

Use of lamotrigine in Lennox-Gastaut and related epilepsy syndromes

Journal of Child Neurology
O Dulac, A Kaminska

Abstract

Lennox-Gastaut syndrome a combination of various generalized seizures including atypical absences and tonic seizures with generalized slow spike waves and mental deterioration, is often difficult to distinguish from a subgroup of myoclonic-astatic epilepsy, other generalized epilepsy syndromes, and various symptomatic generalized epilepsies. Conventional antiepileptic medication is poorly effective in this condition, particularly because various types of seizures respond differently to each given drug. Lamotrigine is effective in the various types of generalized seizures and efficacy has been demonstrated in Lennox-Gastaut syndrome. Given the potential of major mental deterioration within a matter of months in this condition, and the need of slow dose escalation in order to prevent skin rash, lamotrigine should be administered as soon as the diagnosis of Lennox-Gastaut syndrome is suspected. In addition, there is growing evidence that lamotrigine is also most useful in the subgroup of myoclonic-astatic epilepsy beginning in childhood, and that these patients should benefit from the drug like those affected by Lennox-Gastaut syndrome, as soon as the diagnosis is suspected. However, this drug may worsen other cases of myoclonic-a...Continue Reading

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Citations

Apr 2, 2009·Neuropsychiatric Disease and Treatment·Kenou van Rijckevorsel
Feb 13, 2009·Expert Review of Neurotherapeutics·Sylvain Rheims, Philippe Ryvlin
Nov 9, 2005·Expert Review of Neurotherapeutics·Michael KoutroumanidisStella Veronica Tan
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Jan 22, 2004·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Renzo Guerrini, Jean Aicardi

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