Use of Letermovir for Salvage Therapy for Resistant Cytomegalovirus in a Pediatric Hematopoietic Stem Cell Transplant Recipient.

Journal of the Pediatric Infectious Diseases Society
Jacob T KilgoreYeh-Chung Chang

Abstract

We present here the first published use of letermovir for the treatment of resistant cytomegalovirus (CMV) in a pediatric patient. A 14-year-old girl underwent a double unrelated umbilical cord blood transplantation to treat her sickle cell disease (hemoglobin SS) and developed ganciclovir-resistant CMV DNAemia with end-organ involvement that was treated successfully with a combination of foscarnet and letermovir. After she was transitioned to letermovir monotherapy for secondary prophylaxis, she developed recurrent DNAemia with laboratory-confirmed ganciclovir, foscarnet, and letermovir resistance.

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Dec 7, 2017·The New England Journal of Medicine·Francisco M MartyCyrus Badshah

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Citations

Jan 26, 2020·Current Hematologic Malignancy Reports·Morgan Hakki
Apr 25, 2020·Journal of the Pediatric Infectious Diseases Society·Nora IsbernerHartwig Klinker
Nov 11, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ekaterina KachurZainab Shahid

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