Use of lung treatment plans to evaluate DIR algorithms

Australasian Physical & Engineering Sciences in Medicine
Ines-Ana JurkovicPanayiotis Mavroidis

Abstract

The purpose of the study is to evaluate the accuracy of two deformable image registration algorithms by examining their influence on the dose summation results obtained using 4DCT (four dimensional computed tomography) dose distributions based on '4D' planned and '4D optimal' IMRT (intensity modulated radiation therapy) plans. For ten lung cancer patients, 4D step and shoot IMRT plans were produced. The breathing cycle was divided into ten parts and for each part a set of CT images was acquired. For each patient the treatment plan was copied to the CTs of each phase and subsequently recalculated. Each phase CT was then registered to the average intensity projection (AIP) CT using a deformable image registration (DIR) algorithm and the composite dose distribution was then calculated by summing up the deformed dose distributions from all the phases ('4D' treatment plan). The '4D optimal' treatment plan was created by producing an optimal plan on the CTs of each phase of the respiratory cycle and summing up the deformed dose distributions from all the phases. The results indicate that it is possible to map the dose distributions of different breathing phases in lung using DIR, and that different DIR methods and target characterist...Continue Reading

References

Sep 19, 2006·The British Journal of Radiology·M L Kessler
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Mar 22, 2014·Australasian Physical & Engineering Sciences in Medicine·Nicholas HardcastleWolfgang A Tomé
Jul 18, 2017·Radiation Oncology Journal·Seungjong Oh, Siyong Kim

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