PMID: 15357561Sep 11, 2004Paper

Use of magnesium sulphate in severe persistent pulmonary hypertension of the newborn

Journal of Tropical Pediatrics
Suresh ChandranZaw Wint

Abstract

Persistent pulmonary hypertension in the newborn (PPHN) is a neonatal emergency due to the failure to achieve normal cardiopulmonary adaptation following delivery. A clinical trial to assess the efficacy of magnesium sulphate (MgSO4) in the treatment of PPHN was conducted in the tertiary level neonatal intensive care unit of RIPAS Hospital, Brunei Darussalam over a period of 2 years. Twelve newborn babies admitted consecutively to the neonatal intensive care unit with severe hypoxemia due to persistent pulmonary hypertension were included in this trial. A loading dose of 200 mg/kg MgSO4 was given over a period of 20 min, followed by a continuous infusion at the rate of 20-150 mg/kg/h to obtain a serum magnesium level between 3.5 and 5.5 mmol/l. No other vasodilators were used and babies were not hyperventilated. Dopamine was commenced at 5-10 microg/kg/min before the loading dose of MgSO4 was given. Mean blood pressure was maintained with short periods of dopamine alone or in combination with dobutamine. Oxygen index (OI) and alveolar-arterial oxygen gradient (A-aDO2) showed significant improvement within 24 h of treatment. In this study, MgSO4 was found to be a safe and effective pulmonary vasodilator. MgSO4 could be used as a...Continue Reading

Citations

Jun 27, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·E W CoatesT M O'Shea
Nov 19, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·M ParadisisM Kluckow
Jan 15, 2014·Pediatric Pulmonology·Hasan KahveciKezban Ozturk
Jan 6, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bhawan Deep Garg
Feb 1, 2008·Expert Review of Respiratory Medicine·I W J M van der HorstD Tibboel
Jun 10, 2010·Expert Review of Cardiovascular Therapy·Shripada RaoSanjay Patole

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