Use of melatonin as adjunctive therapy in neonatal sepsis: A systematic review and meta-analysis

Complementary Therapies in Medicine
Renésha HendersonEuni Lee

Abstract

Sepsis remains one of the major causes of neonatal mortality and morbidity. Increased production of free radicals and pro-inflammatory cytokines, combined with the innately low levels of plasma antioxidants in neonates, have been implicated in the pathogenesis and complications of neonatal sepsis. To date, few clinical trials on the beneficial effects of exogenous melatonin on improvement of clinical outcomes in septic neonates have been conducted. The electronic databases including PubMed, Embase, and Cochrane Central Register of Controlled Trials were systematically searched on July 2017 for clinical studies that reported the effects of melatonin as an adjuvant therapy in neonatal sepsis. Serum levels of C-reactive protein (CRP) as biomarker endpoint and recovery of sepsis as clinical endpoint were used to compare treatment responses between groups. The Risk of Bias Assessment tool for Non-Randomized Studies (RoBANS) and the Cochrane Collaboration Risk of Bias tool were used to assess the quality of included studies. Three studies with a total of 120 participants were included in the systematic review and meta-analysis. Pooled analysis revealed statistically significant mean differences in CRP serum levels (mg/L) between grou...Continue Reading

Citations

Dec 4, 2019·Expert Review of Clinical Pharmacology·Susanna Esposito, Nicola Principi
Feb 6, 2020·Expert Opinion on Pharmacotherapy·Federico CarboneAmirhossein Sahebkar
Aug 28, 2020·Nutrients·Konrad KleszczyńskiRussel J Reiter
Nov 27, 2018·Military Medical Research·Hui ZhangYong-Ming Yao
Apr 27, 2021·American Journal of Physiology. Endocrinology and Metabolism·K M O'ConnorF B McDonald
Jul 20, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rüdiger Hardeland

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