Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial

The Lancet. Diabetes & Endocrinology
Tone S LøvvikEszter Vanky

Abstract

Women with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy complications. Epi-analysis of two previous randomised controlled trials that compared metformin with placebo during pregnancy in women with PCOS showed a significant reduction in late miscarriages and preterm births in the metformin group. The aim of this third randomised trial (PregMet2) was to test the hypothesis that metformin prevents late miscarriage and preterm birth in women with PCOS. PregMet2 was a randomised, placebo-controlled, double-blind, multicentre trial done at 14 hospitals in Norway, Sweden, and Iceland. Singleton pregnant women with PCOS aged 18-45 years were eligible for inclusion. After receiving information about the study at their first antenatal visit or from the internet, women signed up individually to participate in the study. Participants were randomly assigned (1:1) to receive metformin or placebo by computer-generated random numbers. Randomisation was in blocks of ten for each country and centre; the first block had a random size between one and ten to assure masking. Participants were assigned to receive oral metformin 500 mg twice daily or placebo during the first week of treatment, which increased to 1000 mg twice d...Continue Reading

Citations

Apr 17, 2019·European Journal of Endocrinology·Maria Othelie UnderdalEszter Vanky
Nov 2, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Suhail A R DoiLukman Thalib
May 5, 2020·Aging·Qingjun PanHua-Feng Liu
Jun 17, 2020·Expert Opinion on Investigational Drugs·Luigi Della CortePierluigi Giampaolino
Jul 7, 2020·Frontiers in Pharmacology·Gonzalo JorqueraGonzalo Cruz
Dec 8, 2019·Current Diabetes Reports·Rachel A BlairNadine E Palermo
Oct 14, 2019·Reproductive Biology·Beata BanaszewskaRobert Spaczynski
Dec 5, 2020·Fertility and Sterility·Sonia L Robinson, Edwina H Yeung
Feb 5, 2021·PloS One·Heiddis ValgeirsdottirAnna-Karin Wikström
Feb 2, 2021·Endocrinology and Metabolism Clinics of North America·Amy M Valent, Linda A Barbour
Feb 27, 2021·Expert Review of Endocrinology & Metabolism·Claudia RaperportRoy Homburg
Dec 11, 2020·Human Reproduction Update·Stefano PalombaLinda C Giudice
May 1, 2021·Scientific Reports·Jane L Tarry-AdkinsCatherine E Aiken
Apr 30, 2021·Lancet·Arri CoomarasamySiobhan Quenby
Jul 3, 2021·Journal of Clinical Medicine·Elżbieta Poniedziałek-CzajkowskaBożena Leszczyńska-Gorzelak
Aug 28, 2021·Journal of Clinical Medicine·Carlos Pascual-MorenaVicente Martínez-Vizcaíno
Sep 17, 2021·The Journal of Clinical Endocrinology and Metabolism·Live Marie T StokkelandEszter Vanky
Sep 28, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Christine Newman, Fidelma P Dunne
Nov 9, 2021·Frontiers in Endocrinology·Mélanie C FaurePascal Froment

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