Use of Methadone to Reverse Opioid Escalation in a Patient With Surgical Pain

Journal of Pain & Palliative Care Pharmacotherapy
Muhammad JaffarThomas Webb

Abstract

Acute pain is a prevalent issue for patients recovering from surgical procedures. Methadone has been recognized as a unique option for treatment of surgical pain due to its multiple mechanisms of analgesia and its potential to decrease tolerance to other opioids. Studies of methadone use in postoperative settings are sparse in part due to safety concerns, such as complex pharmacokinetics, risk of respiratory depression, and association with arrhythmias. In this case study of a 70-year-old male with postsurgical abdominal pain, methadone utilization over a period of 9 days resulted in patient-reported analgesia and aided in de-escalating overall opioid use. More studies are needed to develop guidance on how methadone can be used to relieve pain following surgical procedures.

References

Dec 18, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y ShirE M Davidson
Jun 10, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·M M Meyer, R J Berens
Oct 15, 2009·Journal of Palliative Medicine·Suresh ReddyEduardo Bruera
Jul 21, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kevin LaskowskiHyun J Lim
Oct 20, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·G Morgan JonesClaire V Murphy
Dec 28, 2012·Critical Care Medicine·Juliana BarrUNKNOWN American College of Critical Care Medicine
Jul 26, 2014·Acta Anaesthesiologica Scandinavica·E D McNicolS Haroutounian
Mar 16, 2016·JAMA : the Journal of the American Medical Association·Deborah DowellRoger Chou
Jun 12, 2016·Journal of Critical Care·Jessica L ElefritzMichael R Lyaker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

Seminars in Cardiothoracic and Vascular Anesthesia
Jeffrey P Cardinale, George Gilly
Deutsche medizinische Wochenschrift
Bernd Kurz, G A Müller
Revista española de anestesiología y reanimación
C Segura HenríquezL Naharro Román
© 2022 Meta ULC. All rights reserved