Use of mirtazapine in patients with chronic breathlessness: A case series

Palliative Medicine
Natasha LovellIrene J Higginson

Abstract

Breathlessness remains a common and distressing symptom in people with advanced disease with few effective treatment options. Repurposing of existing medicines has been effective in other areas of palliative care, for example, antidepressants to treat pain, and offers an opportunity to deliver improved symptom control in a timely manner. Previous case series have shown reduced breathlessness following the use of sertraline (a selective serotonin reuptake inhibitor) in people with chronic obstructive pulmonary disease. Six cases where mirtazapine, a noradrenergic and specific serotonergic antidepressant, was used to treat chronic breathlessness in advanced lung disease. Case management: All cases received mirtazapine at a starting dose of 15 mg, prescribed under the care of their primary care physician. Cases had been receiving mirtazapine for a variable time period (2 weeks to 5 months) at the time of the interviews. Case outcome: All cases reported less breathlessness and being able to do more. They described feeling more in control of their breathing, and being able to recover more quickly from episodes of breathlessness. Some cases also reported beneficial effects on anxiety, panic, appetite and sleep. No adverse effects wer...Continue Reading

References

Apr 16, 1998·Psychosomatics·J W SmollerR L Kradin
Oct 11, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L RibeiroF Kapczinski
May 27, 2017·The European Respiratory Journal·Miriam J JohnsonDavid C Currow

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Citations

Jan 1, 2019·Expert Review of Respiratory Medicine·N LovellI J Higginson
Jul 4, 2019·Journal of Palliative Medicine·Richard Weinberg, Briana Ketterer
Aug 8, 2020·The Journal of the American Osteopathic Association·Danielle PrenticeRaymond Deiter
Sep 17, 2020·The Journal of the American Osteopathic Association·Masumi G AsahiMichael A Seffinger
Jan 21, 2021·Journal of General Internal Medicine·Annie Massart, Daniel P Hunt
Dec 12, 2020·ESMO Open·David HuiUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Sep 17, 2021·The American Journal of Hospice & Palliative Care·Tan Seng BengNik Nathasha Hani Nik Isahak

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