Use of modified ultrafiltration in adults undergoing coronary artery bypass grafting is associated with inflammatory modulation and less postoperative blood loss: a randomized and controlled study

The Journal of Thoracic and Cardiovascular Surgery
Anali Galluce TorinaOrlando Petrucci

Abstract

Modified ultrafiltration (MUF) has been shown to decrease the postcardiac surgery inflammatory response and to improve respiratory function and cardiac performance in pediatric patients; however, this approach has not been well established in adults. The present study hypothesized that MUF could decrease the postsurgical inflammatory response, leading to improved respiratory and cardiac function in adults undergoing coronary artery bypass grafting. Sixty patients undergoing coronary artery bypass grafting were randomized to the MUF or control group (n = 30 each). MUF was performed for 15 minutes at the end of bypass. The following data were recorded at the beginning of anesthesia, end of bypass, end of experimental treatment, and 24 and 48 hours after surgery: alveolar-arterial oxygen gradient, red blood cell units transfused, chest tube drainage, hemodynamic parameters, and cytokine levels (interleukin-6, P-selectin, intercellular adhesion molecule, and soluble tumor necrosis factor receptor). The MUF group displayed less chest tube drainage than the control group after 48 hours (598 ± 123 mL vs 848.0 ± 455 mL; P = .04) and less red blood cell transfusions (0.6 ± 0.6 units/patient vs 1.6 ± 1.1 units/patient; P = .03). Hematocr...Continue Reading

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Citations

Nov 2, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Nian Chih Hwang
Jan 12, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Carolina KosourReinaldo Wilson Vieira
Nov 27, 2014·Interactive Cardiovascular and Thoracic Surgery·Mustafa ZakkarGianni D Angelini
Apr 15, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Allison Bechtel, Julie Huffmyer
Aug 19, 2015·Journal of the American Heart Association·Michael GoldfarbJonathan Afilalo
Oct 3, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alexander WahbaUNKNOWN EACTS/EACTA/EBCP Committee Reviewers

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