Use of multigeneration-family molecular dog leukocyte antigen typing to select a hematopoietic cell transplant donor for a dog with T-cell lymphoma

Journal of the American Veterinary Medical Association
M LupuR Storb

Abstract

A 7-year-old Golden Retriever was examined because of anorexia, lethargy, vomiting, and gradual weight loss. Splenomegaly, pancytopenia, high serum calcium concentration, and high alkaline phosphatase activity were detected. Magnetic resonance imaging revealed an enlarged mesenteric lymph node and increased signals from the bone marrow of the ilium and vertebral bodies. Histologic examination and immunophenotyping of biopsy specimens confirmed a stage V (b) T-cell malignant lymphoma. Clinical remission was attained by use of 2 chemotherapy cycles, followed by an allogeneic hematopoietic cell transplant performed at 18 weeks after diagnosis. A donor was identified by molecular dog leukocyte antigen typing methods. The patient was conditioned with 2 fractions of 4 Gy total body irradiation delivered 3 hours apart at 7 cGy/min, followed by an IV infusion of recombinant canine granulocyte colony-stimulating factor mobilized leukapheresis product and postgrafting immunosuppression with cyclosporine. Chimerism analyses revealed full donor engraftment that has been maintained for at least 58 weeks after transplant. Remission has been confirmed by normal results of serum thymidine kinase assays and the absence of peripheral blood clona...Continue Reading

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Citations

Aug 14, 2012·Journal of Veterinary Internal Medicine·J L WillcoxS E Suter
Oct 4, 2011·American Journal of Veterinary Research·Masahiko SatoHajime Tsujimoto
Jun 18, 2014·ILAR Journal·Colleen M O'Connor, Heather Wilson-Robles
May 18, 2010·The Veterinary Clinics of North America. Small Animal Practice·Barrak M Pressler
Nov 4, 2008·Veterinary Immunology and Immunopathology·Jumpei YamazakiHajime Tsujimoto
Mar 2, 2013·Veterinary Anaesthesia and Analgesia·Lysa P PosnerSteven E Suter
Oct 2, 2013·Chimerism·Senthil R KumarJeffrey N Bryan
Apr 16, 2015·Journal of the American Veterinary Medical Association·Steven E SuterGopalakrishnan M Venkataraman
May 10, 2020·Veterinary and Comparative Oncology·Scott S Graves, Rainer Storb

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