PMID: 2112167May 1, 1990Paper

Use of mupirocin ointment in the treatment of secondarily infected dermatoses

Journal of the American Academy of Dermatology
D L Breneman

Abstract

A double-blind, randomized, vehicle-controlled study was conducted to evaluate the safety and efficacy of 2% mupirocin ointment in the treatment of secondarily infected dermatoses. One hundred six patients were enrolled, 92 of whom were evaluable for efficacy. There was a significantly greater rate of eradication of Staphylococcus aureus and total pathogens in mupirocin-treated patients than in control subjects. Analysis of the clinical data relative to all pathogens showed a significant difference in skin infection evaluations performed at the interim and follow-up visits, which favored the mupirocin-treated groups. In those patients infected with S. aureus or Streptococcus pyogenes, there was a significant difference at end-point that favored mupirocin in seven clinical ratings and the skin infection evaluation at follow-up. Mild local adverse effects were noted in a small percentage of patients in each group. Mupirocin appears to be safe and effective for the treatment of secondarily infected dermatoses, especially in those infections caused by Staphylococcus aureus.

References

Feb 1, 1977·The British Journal of Dermatology·J J Leyden, A M Kligman
Jan 1, 1986·Clinical and Experimental Dermatology·M I White, W C Noble
Jan 1, 1986·Archives of Disease in Childhood·T J David, G C Cambridge
May 1, 1974·The British Journal of Dermatology·J J LeydenA M Kligman
Oct 1, 1983·Archives of Dermatology·M V Dahl

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Citations

Feb 9, 1999·The Journal of Emergency Medicine·P M Williford
Feb 9, 1999·The Journal of Emergency Medicine·J Bikowski
Aug 11, 2004·American Journal of Clinical Dermatology·Iain B Gosbell
Oct 4, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Arnold P OranjeUNKNOWN TOC100224 Study Team
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Andrew J BirnieHywel C Williams
Oct 7, 2009·Expert Review of Anti-infective Therapy·Ronald PangilinanGlenn Tillotson
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Susannah Mc GeorgeHywel C Williams
Jun 1, 2000·Infectious Disease Clinics of North America·E T Kaye

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