Use of muscle-vein-combined Y-chambers for repair of multiple nerve lesions: experimental results

Microsurgery
P TosB Battiston

Abstract

Y-shaped vein conduits enriched with fresh skeletal muscle fibers were used to bridge a concomitant ulnar and median nerve transection with substance loss in rats. The proximal limb of the Y-chamber was sutured to the proximal ulnar nerve, while the two distal limbs were sutured to ulnar and median distal nerve stumps. Eight months after surgery, median nerve functional recovery was evaluated by means of the grasping test, and nerve fiber regeneration in both repaired nerves was assessed by means of design-based histomorphometry. Results showed that nerve fibers regenerated along both severed nerve trunks, and in the median nerve led to a recovery corresponding to 58% of normal nerve function. Quantitative analysis showed no significant morphological differences between myelinated nerve fibers regenerated along the two distal nerves except for the number of fibers, which was higher in the median nerve. Notably, the total number of regenerated nerve fibers in the two distal nerves was 4-fold the normal fiber number in the ulnar nerve. Besides their interest in relation to the long-lasting debate about the topographic specificity of nerve regeneration, the results of this study show an effective way to repair, in the rat experime...Continue Reading

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Citations

Jan 8, 2008·Plastic and Reconstructive Surgery·Stefano Geuna, Pierlugi Tos
Mar 13, 2014·Journal of Brachial Plexus and Peripheral Nerve Injury·Stefano GeunaBruno Battiston
Jun 10, 2009·Journal of Neuroscience Methods·Frank WerdinNektarios Sinis
Aug 16, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Fabrizio SchonauerGuido Molea
Jun 29, 2005·The Journal of Comparative Neurology·Stefania RaimondoStefano Geuna
Apr 17, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ana Paula SantosAmilton Antunes Barreira
Nov 18, 2005·Injury·Elizabeth O JohnsonPanayotis N Soucacos
Mar 22, 2007·Journal of the Peripheral Nervous System : JPNS·Clare M Galtrey, James W Fawcett
Feb 22, 2007·Plastic and Reconstructive Surgery·Nektarios SinisHans-Eberhard Schaller
Jul 19, 2019·Frontiers in Cellular Neuroscience·Giulia RonchiGiovanna Gambarotta

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