Use of myocardial scar characterization to predict ventricular arrhythmia in cardiac resynchronization therapy

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Juan Fernández-ArmentaJosep Brugada

Abstract

There is insufficient evidence to implant a combined cardiac resynchronization therapy (CRT) device with defibrillation capabilities (CRT-D) in all CRT candidates. The aim of the study was to assess myocardial scar size and its heterogeneity as predictors of sudden cardiac death (SCD) in CRT candidates. A cohort of 78 consecutive patients with dilated cardiomyopathy and class I indication for CRT-D were prospectively enrolled. Before CRT-D implantation, a contrast-enhanced cardiac magnetic resonance (ce-CMR) was performed. The core and border zone (BZ) of the myocardial scar were characterized and quantified with a customized post-processing software. The first appropriate implantable cardioverter defibrillator (ICD) therapy was considered as a surrogate of SCD. During a mean follow-up of 25 months (25-75th percentiles, 15-34), appropriate ICD therapy occurred in 11.5% of patients. In a multivariate Cox proportional hazards regression model for clinical and ce-CMR variables, the scar mass percentage [hazards ratio (HR) per 1% increase 1.1 (1.06-1.15), P < 0.01], the BZ mass [HR per 1 g increase 1.06 (1.04-1.09), P < 0.01], and the BZ percentage of the scar [HR per 1% increase 1.06 (1.02-1.11), P < 0.01], were the only independe...Continue Reading

References

May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Jun 15, 2004·Journal of the American College of Cardiology·James C C MoonDudley J Pennell
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Apr 6, 2005·Journal of the American College of Cardiology·David BelloJeffrey J Goldberger
Apr 16, 2005·European Heart Journal·Heiko MahrholdtRaymond J Kim
Nov 23, 2006·Journal of the American College of Cardiology·Ravi G AssomullDudley J Pennell
Jun 21, 2008·Journal of the American College of Cardiology·Katherine C WuJoão A C Lima
Mar 28, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Iwona CygankiewiczUNKNOWN MADIT II Investigators
Sep 3, 2009·European Heart Journal·Kenneth DicksteinUNKNOWN National Coordinators

❮ Previous
Next ❯

Citations

Oct 19, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·David ŽižekIgor Zupan
Oct 26, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kenneth C Bilchick
Jan 18, 2013·European Heart Journal Cardiovascular Imaging·Sophie MavrogeniEfstathios Iliodromitis
Aug 16, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Marcello DisertoriEloisa Arbustini
Nov 5, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Joachim AlexandrePaul Milliez
Apr 1, 2015·Expert Review of Cardiovascular Therapy·Alain NchimiPatrizio Lancellotti
Jul 3, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Amit K Mehrotra, David Callans
Nov 26, 2015·Cardiac Electrophysiology Clinics·José María Tolosana, Lluís Mont
Jan 15, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Zak LoringKatherine C Wu
Apr 25, 2016·Revista Española De Cardiología·Laura SanchisMarta Sitges
Dec 4, 2014·Journal of Electrocardiology·Rossella BaniLuigi Padeletti
Apr 14, 2016·Pacing and Clinical Electrophysiology : PACE·Sarfaraz MemonJeffrey Kluger
Sep 21, 2016·Current Treatment Options in Cardiovascular Medicine·Mrinal Yadava, Michael D Shapiro
Jan 21, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Diego PenelaAntonio Berruezo
Dec 1, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Maria Lucia NarducciFilippo Crea
May 21, 2013·Circulation. Arrhythmia and Electrophysiology·Juan Fernández-ArmentaJosep Brugada
Apr 1, 2020·Journal of Cardiovascular Electrophysiology·Katarzyna Malaczynska-RajpoldStefan Grajek
Jun 9, 2020·Current Heart Failure Reports·Vincent GalandChristophe Leclercq
Oct 6, 2020·Cardiology Research and Practice·Martina NestiLuigi Sciarra
Feb 17, 2017·Herzschrittmachertherapie & Elektrophysiologie·Martin GrettHans-Joachim Trappe
Feb 23, 2020·JACC. Clinical Electrophysiology·Beatriz JáureguiAntonio Berruezo
Mar 23, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fatemeh CheginiMartin Weiser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.