Use of N-terminal pro-brain natriuretic peptide to detect cardiac origin in critically ill cancer patients with acute respiratory failure.

Intensive Care Medicine
Aurélie LefebvreElie Azoulay

Abstract

To assess the accuracy of plasma N-terminal-pro-B-type natriuretic peptide concentrations (NT-proBNP) as a diagnostic tool to recognize acute respiratory failure (ARF) of cardiac origin. Prospective observational study in 100 medical intensive care unit (ICU) patients. NT-proBNP was measured at ICU admission, and diagnosis of cardiac dysfunction was performed using echocardiography. Sixteen patients had cardiac ARF, 58 patients had noncardiac ARF, and 26 patients were non-ARF controls. Median (IQR) NT-proBNP was 1,951 (617-9,320) pg/ml and was significantly influenced by the level of renal dysfunction. Patients with noncardiac ARF had higher NT-proBNP [1,912 (704-1,922) pg/ml] than non-ARF patients [1,022 (383-2,613) pg/ml], but lower concentrations than cardiac ARF patients [4,536 (1,568-35,171) pg/ml]. The area under the curve (AUC) was 0.663+/-0.078 (95% confidence interval 0.510-0.815) and was not significantly influenced by the level of renal dysfunction. In addition, using a stepwise logistic regression model, NT-proBNP failed to predict independently the presence of cardiac dysfunction. However, with specificity and negative predictive value of 100%, a NT-proBNP cutoff value of 500 pg/ml seemed useful to rule out cardiac...Continue Reading

References

Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
Sep 11, 1996·JAMA : the Journal of the American Medical Association·J R Le GallD Teres
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S GroegerK Price
Jun 11, 1999·The European Respiratory Journal·D GrusonJ P Cardinaud
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·J P KressJ B Hall
Jan 4, 2001·The New England Journal of Medicine·S K GandhiW C Little
Feb 24, 2001·Journal of the American College of Cardiology·Q DaoA S Maisel
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M T MeinardiW T van der Graaf
Jul 19, 2002·The New England Journal of Medicine·Alan S MaiselUNKNOWN Breathing Not Properly Multinational Study Investigators
Nov 5, 2004·Medicine·Élie AzoulayBenoît Schlemmer
Jan 12, 2005·European Journal of Heart Failure·Gedske DaugaardAndreas Kjaer
May 17, 2005·Journal of the American College of Cardiology·Paul R ForfiaEdward P Shapiro
Feb 24, 2006·American Journal of Surgery·Michael KiaDouglas Iddings
May 23, 2006·Bone Marrow Transplantation·N J Bahlis, H M Lazarus
May 23, 2006·Intensive Care Medicine·Elie Azoulay, Benoît Schlemmer
Dec 5, 2006·European Journal of Internal Medicine·Renana ShorAaron Halabe
Jun 7, 2007·American Journal of Clinical Oncology·Sukesh C BurjonroppaDaniel J Lenihan

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