Use of neuromuscular blockers and neostigmine for general anesthesia and its association with neuraxial blockade: A retrospective study

Filipe Nadir Caparica SantosVanessa Henriques Carvalho


This research aimed to assess the use of neuromuscular blockers (NMB) and its reversal, associated or not with neuraxial blockade, after general anesthesia.This retrospective study analyzed 1295 patients that underwent surgery with general anesthesia at Prof. Dr. José Aristodemo Pinotti Hospital in 2013. The study included patients aged >1 year, with complete, readable medical charts and anesthetic records.Rocuronium (ROC) was the most used NMB (96.7%), with an initial dose of 0.60 (0.52-0.74) mg/kg and total dose of 0.38 (0.27-0.53) mg/kg/h. In 24.3% of the cases, neuraxial blockade was associated with a significantly longer anesthesia (P < .001) than in cases without neuraxial block, regardless of technique (total intravenous (TIV) vs intravenous and inhalational (IV+IN)). In 71.9% of the cases, a single dose of NMB was used. Patients under TIV general anesthesia associated with neuraxial blockade had a lower total dose of ROC (mg/kg/h) in comparison with TIV GA alone (0.30 (0.23-0.39) and 0.42 (0.30-0.56) mg/kg/h, respectively, P < .001). The same was observed for patients under IV+IN GA (0.32 (0.23-0.41) and 0.43 (0.31-0.56) mg/kg/h, respectively, P < .001). The duration of anesthesia was longer according to increasing numb...Continue Reading


Jan 1, 1996·Acta Anaesthesiologica Scandinavica·J Viby-MogensenD Ostergaard
Jul 21, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H WulfD Sitzlack
May 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J E ReidA H Hayes
Dec 26, 2001·Anesthesiology·Hans KirkegaardJames E Caldwell
Jul 2, 2003·Der Anaesthesist·T Fuchs-BuderManfred Blobner
Jun 19, 2008·British Journal of Anaesthesia·Matthias EikermannN L Chamberlin
Jun 24, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·P DuvaldestinP Maison
Feb 19, 2009·Anaesthesia·C ClaudiusJ Viby-Mogensen
Feb 19, 2009·Anaesthesia·Aaron F Kopman, Matthias Eikermann
May 27, 2009·British Journal of Anaesthesia·A Srivastava, J M Hunter
Dec 1, 2004·Revista brasileira de anestesiologia·Maria Cristina Simões de Almeida
Sep 1, 2002·Revista brasileira de anestesiologia·Angélica de Fátima de Assunção BragaGislaine Mauro
Aug 20, 2009·Anesthesia and Analgesia·Christian S MeyhoffLars S Rasmussen
Nov 17, 2009·Anesthesia and Analgesia·Mohamed NaguibSorin J Brull
Dec 17, 2009·Revista brasileira de anestesiologia·Angélica de Fátima de Assunção BragaGloria Maria Braga Potério
Dec 22, 2010·British Journal of Anaesthesia·J Ingrande, H J M Lemmens
Aug 26, 2011·Anesthesia and Analgesia·Rogerio L R Videira, Joaquim E Vieira
Jun 13, 2013·Anesthesia and Analgesia·Yoshifumi KotakeJunzo Takeda
Dec 10, 2013·Acta Cirúrgica Brasileira·Angélica de Fátima de Assunção BragaFilipe Nadir Caparica Santos
Dec 23, 2014·Current Anesthesiology Reports·Hassan FarhanMatthias Eikermann
Jul 11, 2015·Revista brasileira de anestesiologia·Giovani de Figueiredo LocksMaria Cristina Simões de Almeida
Aug 4, 2016·Acta Cirúrgica Brasileira·Vanessa Henriques CarvalhoFernando Eduardo Feres Junqueira

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General Anesthesia
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