Use of nicotine replacement therapy during pregnancy and stillbirth: a cohort study

BJOG : an International Journal of Obstetrics and Gynaecology
Katrine Strandberg-LarsenM Grønbaek

Abstract

The objective of this study was to examine whether the use of nicotine replacement therapy (NRT) during pregnancy increases the risk of stillbirth. Cohort study with prospective data. Denmark 1996-2002. A total of 87,032 singleton pregnancies enrolled in the Danish National Birth Cohort for which information on NRT use as well as smoking was available. Outcome of pregnancy was identified by register linkage, with <1% loss to follow up. We conducted Cox regression analyses to estimate the hazard ratio (HR) and 95% CI of stillbirth according to the use of NRT, type of NRT use and a combination of NRT use and smoking. Stillbirth, defined as delivery of a dead fetus after 20 completed weeks of gestation. A total of 495 pregnancies (5.7 in 1000 births) ended in stillbirth, 8 of which were among NRT users (4.2 in 1000 births). After adjustment for confounders, women who used NRT during pregnancy had a HR of 0.57 (95% CI 0.28-1.16) for stillbirth compared with those who did not use NRT. Smoking during pregnancy was associated with an increased risk of stillbirth (HR 1.46, 95% CI 1.17-1.82), while women who both smoked and used NRT had a HR of 0.83 (95% CI 0.34-2.00) compared with nonsmoking women who did not use NRT. Our study does no...Continue Reading

References

Apr 1, 1994·British Journal of Obstetrics and Gynaecology·E G RaymondJ L Kiely
Apr 1, 1996·Seminars in Perinatology·D S Lambers, K E Clark
Oct 17, 1998·Acta Obstetricia Et Gynecologica Scandinavica·K WisborgN J Secher
May 18, 1999·Acta Obstetricia Et Gynecologica Scandinavica·I Ahlenius, P Thomassen
Nov 21, 2000·Obstetrics and Gynecology·K WisborgN J Secher
May 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D A Dempsey, N L Benowitz
Aug 10, 2001·American Journal of Epidemiology·K WisborgN J Secher
Jan 5, 2002·Scandinavian Journal of Public Health·J OlsenC Søndergaard
Mar 6, 2002·Seminars in Perinatology·Sven Cnattingius, Olof Stephansson
Apr 9, 2002·Current Biology : CB·Joel H Rothman
Nov 22, 2002·Lancet·Anne-Marie Nybo AndersenMads Melbye
Jan 8, 2004·American Journal of Obstetrics and Gynecology·Jodie M DoddAnnabelle Chan
Apr 10, 2004·BMJ : British Medical Journal·Ann McNeill
Apr 24, 2004·BMJ : British Medical Journal·Tim ColemanJim Thornton
Jul 22, 2004·The Cochrane Database of Systematic Reviews·C SilagyG Fowler
Aug 11, 2004·Journal of Consulting and Clinical Psychology·Antonio Cepeda-BenitoStephen Erath
Aug 9, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Rachel HerbertJohn Britton
Dec 6, 2005·American Journal of Obstetrics and Gynecology·Ruth C Fretts
Jan 6, 2006·Obstetrics and Gynecology·María M Morales-Suárez-VarelaJorn Olsen
Jan 25, 2006·Annals of Epidemiology·Linda DoddsCarl Nimrod
Jun 7, 2006·Epidemiology·Ellen Aagaard NohrJorn Olsen

❮ Previous
Next ❯

Citations

Nov 8, 2008·Nature Medicine·Erika Check Hayden
Sep 1, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Cheryl A Oncken, H R Kranzler
Nov 1, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Brian J Piper, Selena M Corbett
Apr 7, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer E BruinAlison C Holloway
Mar 11, 2010·MCN. the American Journal of Maternal Child Nursing·Sharron Forest
May 14, 2009·BMC Pregnancy and Childbirth·Mohammad Yawar YakoobZulfiqar A Bhutta
Dec 27, 2013·Asian Journal of Andrology·Linn Berger HåkonsenCecilia Høst Ramlau-Hansen
Jul 30, 2011·Seminars in Perinatology·Carol J Rowland Hogue, Robert M Silver
May 23, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Niharika MehtaRaumond Powrie
Oct 5, 2016·Archives of Toxicology·Peter N Lee, Marc W Fariss
Aug 15, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sachiko BabaSven Cnattingius
Aug 4, 2011·Scandinavian Journal of Public Health·Anne-Marie Nybo Andersen, Jørn Olsen
Nov 28, 2013·Pharmaceuticals·Bengt KällénMargareta Reis
Sep 3, 2014·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Nafeesa N DhalwaniLaila J Tata
Oct 18, 2018·Expert Opinion on Pharmacotherapy·Jose Barboza
Feb 3, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Nafeesa N DhalwaniLaila J Tata
Jan 11, 2018·The Medical Journal of Australia·Yael Bar-ZeevGillian S Gould
Dec 19, 2019·International Journal of Environmental Research and Public Health·Sebastian SailerOscar García-Algar
Aug 9, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laiba JamshedAlison C Holloway
Jul 30, 2021·Biochemical Pharmacology·Abdalla M WednMahmoud M El-Mas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.