PMID: 16524544Mar 10, 2006Paper

Use of nitazoxanide for gastrointestinal tract infections: treatment of protozoan parasitic infection and beyond

Current Infectious Disease Reports
David A Bobak

Abstract

The United States Food and Drug Administration has approved the parasiticidal agent nitazoxanide for treatment of diarrhea caused by Giardia lamblia/intestinalis or Cryptosporidium parvum. This novel agent has a broad spectrum of activity against many other gastrointestinal pathogens, including bacteria, roundworms, flatworms, and flukes. Nitazoxanide is used in many areas of the world, especially in Central and South America, as a broad-spectrum parasiticidal agent in adults and children. Nitazoxanide appears to be well tolerated, has a relatively low incidence of adverse effect, and displays no significant known drug-to-drug interactions. Recently, preliminary reports indicate that nitazoxanide may be an effective treatment for Clostridium difficile-associated diarrhea as well. Future work will likely solidify and further expand the role of nitazoxanide in the treatment of a wide range of intestinal pathogens.

References

Oct 1, 1996·Antimicrobial Agents and Chemotherapy·L DubreuilJ F Rossignol
Oct 31, 1998·Antimicrobial Agents and Chemotherapy·F MégraudJ F Rossignol
May 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·J F RossignolM S Ayers
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·C S McVay, R D Rolfe
Dec 26, 2001·The Journal of Antimicrobial Chemotherapy·I Sullayman AdaguJean-François Rossignol
May 31, 2002·The New England Journal of Medicine·Xian-Ming ChenNicholas F LaRusso
Jun 12, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jave Ortiz JuanLoic Favennec
Jul 26, 2002·The American Journal of Tropical Medicine and Hygiene·Cesar E Davila-GutierrezMiguel Huerta
Aug 23, 2002·Microbes and Infection·Rebecca A DillinghamRichard L Guerrant
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Marianne StettlerAndrew Hemphill
May 2, 2003·Nihon rinsho. Japanese journal of clinical medicine·Takuro EndoShinji Izumiyama
May 31, 2003·Gastrointestinal Endoscopy·Benjamin LebwohlPeter H R Green
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Yvonne GuttnerBarry J Marshall
Jan 17, 2004·Clinical Microbiology Reviews·Lihua XiaoSteve J Upton
Mar 3, 2004·The Annals of Pharmacotherapy·Jason M Bailey, John Erramouspe
Jul 30, 2004·The Journal of Antimicrobial Chemotherapy·Mirjam WalkerAndrew Hemphill
Oct 16, 2004·Expert Review of Anti-infective Therapy·Clinton A White
Oct 21, 2004·Seminars in Pediatric Infectious Diseases·David B HuangPablo C Okhuysen
Dec 18, 2004·Advances in Parasitology·R C A Thompson, P T Monis
Jan 11, 2005·Current Opinion in Infectious Diseases·Huw V Smith, Gerard D Corcoran
Mar 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·LeAnne M Fox, Louis D Saravolatz
Jul 7, 2005·The Pediatric Infectious Disease Journal·Theresa J Ochoa, A Clinton White
Jul 12, 2005·Chemotherapy·E M ZardiA Afeltra
Jul 28, 2005·Trends in Parasitology·Simone M CacciòHuw V Smith
Jul 30, 2005·BMJ : British Medical Journal·Sean C Sweetman

❮ Previous
Next ❯

Citations

Sep 18, 2007·Parasitology Research·Henri VielChristophe Chartier
Mar 20, 2008·Annals of Tropical Medicine and Parasitology·A A EscobedoR Pérez
Aug 28, 2007·Molecular and Biochemical Parasitology·Roberta M O'ConnorHonorine D Ward
Mar 20, 2008·Maternal & Child Nutrition·Andrew HallNilanthi de Silva
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·Z ZhaoX Meng
Apr 14, 2016·The American Journal of Gastroenterology·Mark S RiddleBradley A Connor
Mar 21, 2012·International Immunopharmacology·Seong Keun HongSeung Yong Park
Jul 28, 2009·Molecular and Biochemical Parasitology·Wei LiXichen Zhang
Nov 19, 2011·The Pediatric Infectious Disease Journal·Olivier VandenbergJack Levy
Feb 7, 2018·Indian Journal of Medical Microbiology·Kumar Saurabh, Shilpi Ranjan

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.