Use of nitroglycerin ointment to treat primary and secondary Raynaud's phenomenon: a systematic literature review

Rheumatology International
Olivia QiuEvelyn R Hermes-DeSantis

Abstract

Raynaud's phenomenon (RP) is a microvascular condition in which reversible ischemic attacks occur in the extremities. Due to the unpredictable nature of these attacks, pharmacologic agents that can be administered on as-needed basis are currently being sought after. Topical nitrates are well suited for as-needed use, and several different formulations have been studied for the treatment of RP, including ointments, gels, patches, and tapes. However, these different dosage forms are not all equal in terms of safety and efficacy, and not every one is commercially available for use in clinical practice. Nitroglycerin ointment is commercially available, and it has less systemic side effects than other topical formulations. Since its role in the treatment of RP has not yet been completely established, we performed a systematic search of Medline, Embase, and the Cochrane Central Register of Controlled Trials to evaluate its safety and efficacy. A total of 1125 studies were identified, and 7 were included in our review. Although the included studies used different measures of efficacy, the majority reported positive responses to nitroglycerin ointment. The benefit of nitroglycerin ointment in the treatment of RP may be further realized...Continue Reading

References

May 1, 1986·Geriatric Nursing·B Todd
Jan 1, 1986·Postgraduate Medical Journal·J S CoppockM J Kendall
Aug 18, 2001·Arthritis and Rheumatism·A E ThompsonJ E Pope
Oct 2, 2002·Arthritis and Rheumatism·Peter A MerkelUNKNOWN Scleroderma Clinical Trials Consortium
Jun 12, 2010·Cardiology in Review·Vaughn E NossamanPhilip J Kadowitz
Jun 20, 2012·Archives of Internal Medicine·Evren CaglayanStephan Rosenkranz
Feb 5, 2014·Journal of Autoimmunity·Emanual MaverakisM Eric Gershwin
Jan 1, 2010·International Journal of Clinical Rheumatology·Zsuzsanna H McMahan, Fredrick M Wigley
Nov 17, 2015·The Journal of Rheumatology·Pia MoinzadehUNKNOWN German Network for Systemic Scleroderma
Aug 11, 2016·The New England Journal of Medicine·Fredrick M Wigley, Nicholas A Flavahan
Aug 20, 2016·Current Opinion in Rheumatology·Ariane L Herrick
Sep 13, 2017·VASA. Zeitschrift für Gefässkrankheiten·Jill BelchZan Zeman

❮ Previous
Next ❯

Citations

Jul 24, 2020·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Philip O Anderson
Sep 30, 2020·Vascular Medicine·Georgiana Pintea BenteaElie Cogan
Dec 7, 2018·The International Journal of Lower Extremity Wounds·Eran ShavitR Gary Sibbald
Aug 23, 2021·Current Opinion in Rheumatology·Ariane L Herrick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Related Papers

Revista de medicină internă, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicină internă
V FicaD Olteanu
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
S A JamalC J Hamilton
© 2022 Meta ULC. All rights reserved