Use of Nonantiretroviral Medications That May Impact Neurocognition: Patterns and Predictors in a Large, Long-Term HIV Cohort Study

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Kendra K RadtkeLeah H Rubin

Abstract

Neurocognitive impairment is a frequent and often disabling comorbidity of HIV infection. In addition to antiretroviral therapies, individuals with HIV infection may commonly use nonantiretroviral medications that are known to cause neurocognitive adverse effects (NC-AE). The contribution of NC-AE to neurocognitive impairment is rarely considered in the context of HIV and could explain part of the variability in neurocognitive performance among individuals with HIV. Women's Interagency HIV Study, a prospective, multisite, observational study of US women with and without HIV. After a literature review, 79 medications (excluding statins) with NC-AE were identified and reported by Women's Interagency HIV Study participants. We examined factors associated with self-reported use of these medications over a 10-year period. Generalized estimating equations for binary outcomes were used to assess sociodemographic, behavioral, and clinical characteristics associated with NC-AE medication use. Three thousand three hundred women (71% with HIV) and data from ∼42,000 visits were studied. HIV infection was associated with NC-AE medication use (odds ratio = 1.52; 95% confidence interval: 1.35 to 1.71). After adjustment for HIV infection statu...Continue Reading

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Citations

May 22, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Leah H RubinJeffrey R Bishop
Jan 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anjali SharmaLeah H Rubin
Jul 29, 2020·Journal of Neurovirology·Precious AmusanEsther Fujiwara
Jan 21, 2019·Current HIV/AIDS Reports·Leah H Rubin, Pauline M Maki
Mar 9, 2021·Frontiers in Neurology·Raha M DastgheybLeah H Rubin
Apr 9, 2021·The American Journal of Clinical Nutrition·Leah H RubinSheri D Weiser
Aug 20, 2021·AIDS·José DamasUNKNOWN and the NAMACO study group

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