Mar 27, 2020

Use of oral anticoagulation therapy in the first 3 months after the diagnosis of atrial fibrillation in Israel: a population-based study

Journal of Cardiovascular Electrophysiology
Louise KezerleMoti Haim

Abstract

Oral anticoagulation therapy (OAC) reduces the risk of ischemic stroke in patients with atrial fibrillation (AF) while increasing the risk of bleeding. Recently, non-vitamin K antagonist oral anticoagulants (NOACs) have become available with lower rates of intracranial bleeding and with some of them major bleeding. The purpose of this study is to evaluate the change in purchasing patterns of OACs (both warfarin and NOACs) over time in AF patients according to stroke and bleeding risk, in the first three months after diagnosis. We conducted a historical cohort study using the Clalit Health Services electronic medical records database. The study population included all members aged ≥ 21 years, with a new diagnosis of non-valvular AF between 2008 and 2015. A total of 58,385 cases were identified. The mean age was 73.1 (±14.1) years and 52.3% were women. The median CHA2 DS2 -VASc score was 4 (IQR 3-5). OACs were purchased by 19,705 patients (33.8%) within the first three months of AF first diagnosis, with patients at higher embolic risk as stratified by the CHA2 DS2 -VASc score, having higher purchasing rates (37.1%). Between 2008-2010, 29% of patients purchased a vitamin K antagonist, the only available OAC at the time. OAC purcha...Continue Reading

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Mentioned in this Paper

Non-Human Protein
Finding
Warfarin
Intracranial Hemorrhages
Cohort
Vitamin K antagonists
Study
Hemorrhage
Ischemic Stroke
Anticoagulants, Oral

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