Mar 27, 2020

Use of oral anticoagulation therapy in the first 3 months after the diagnosis of atrial fibrillation in Israel: a population-based study

Journal of Cardiovascular Electrophysiology
Louise KezerleMoti Haim


Oral anticoagulation therapy (OAC) reduces the risk of ischemic stroke in patients with atrial fibrillation (AF) while increasing the risk of bleeding. Recently, non-vitamin K antagonist oral anticoagulants (NOACs) have become available with lower rates of intracranial bleeding and with some of them major bleeding. The purpose of this study is to evaluate the change in purchasing patterns of OACs (both warfarin and NOACs) over time in AF patients according to stroke and bleeding risk, in the first three months after diagnosis. We conducted a historical cohort study using the Clalit Health Services electronic medical records database. The study population included all members aged ≥ 21 years, with a new diagnosis of non-valvular AF between 2008 and 2015. A total of 58,385 cases were identified. The mean age was 73.1 (±14.1) years and 52.3% were women. The median CHA2 DS2 -VASc score was 4 (IQR 3-5). OACs were purchased by 19,705 patients (33.8%) within the first three months of AF first diagnosis, with patients at higher embolic risk as stratified by the CHA2 DS2 -VASc score, having higher purchasing rates (37.1%). Between 2008-2010, 29% of patients purchased a vitamin K antagonist, the only available OAC at the time. OAC purcha...Continue Reading

  • References35
  • Citations


  • References35
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Non-Human Protein
Intracranial Hemorrhages
Vitamin K antagonists
Ischemic Stroke
Anticoagulants, Oral

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.