Use of organic nitrates and the risk of hip fracture: a population-based case-control study.

The Journal of Clinical Endocrinology and Metabolism
Sander PouwelsF de Vries

Abstract

Use of organic nitrates has been associated with increased bone mineral density. Moreover, a large Danish case-control study reported a decreased fracture risk. However, the association with duration of nitrate use, dose frequency, and impact of discontinuation has not been extensively studied. Our objective was to evaluate the association between organic nitrates and hip fracture risk. A case-control study was conducted using the Dutch PHARMO Record Linkage System (1991-2002, n = 6,763 hip fracture cases and 26,341 controls). Cases had their first admission for hip fracture, whereas controls had not sustained any fracture after enrollment. Current users of organic nitrates were patients who had received a prescription within 90 d before the index date. The analyses were adjusted for disease and drug history. Current use of nitrates was not associated with a decreased risk of hip fracture [adjusted odds ratio (OR) = 0.93; 95% confidence interval (CI) = 0.83-1.04]. Those who used as-needed medication only had a lower risk of hip fracture (adjusted OR = 0.83; 95% CI = 0.63-1.08) compared with users of maintenance medication only (adjusted OR = 1.17; 95% CI = 0.97-1.40). No association was found between duration of nitrate use and...Continue Reading

References

Sep 24, 1987·The New England Journal of Medicine·M PackerM Yushak
Jul 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S H RalstonN Benjamin
Mar 23, 1995·The New England Journal of Medicine·S R CummingsT M Vogt
Jan 1, 1996·Journal of Clinical Epidemiology·R M HeringsA Stergachis
May 30, 1996·The American Journal of Cardiology·U Elkayam
Apr 1, 1996·Clinical Cardiology·P Carson
Nov 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S A JamalS R Cummings
Jan 5, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K E ArmourS H Ralston
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S WimalawansaS Wimalawansa
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sophie A JamalGillian A Hawker
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Eloy SchulzVicente Gilsanz
Apr 19, 2006·Journal of Cellular Biochemistry·G ArasapamC J Xian
Oct 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lars RejnmarkLeif Mosekilde
Feb 20, 2007·Calcified Tissue International·F de VriesT P van Staa
May 6, 2008·Plastic and Reconstructive Surgery·Ines C LinRichard E Kirschner
Sep 19, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A JamalR G Josse
Sep 23, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ashraf F Nabhan, Noha H Rabie
Jun 25, 2009·The Journal of Clinical Endocrinology and Metabolism·Sunil J WimalawansaDonald R Hoover

❮ Previous
Next ❯

Citations

Oct 17, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B AbrahamsenR Eastell
Jan 12, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A JamalC J Hamilton
Jan 3, 2012·Current Osteoporosis Reports·Sophie A Jamal, Celeste J Hamilton
Aug 24, 2012·Current Osteoporosis Reports·Aloice O AluochLaura Carbone
Jan 15, 2014·BoneKEy Reports·Celeste J HamiltonSophie A Jamal
Dec 20, 2011·Calcified Tissue International·Arief LalmohamedFrank de Vries
Oct 12, 2012·Calcified Tissue International·Corinne KlopPaco M J Welsing
Nov 29, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A LalmohamedF De Vries
Dec 6, 2011·Trends in Endocrinology and Metabolism : TEM·Jennifer S WalshRichard Eastell
Oct 26, 2011·Rheumatic Diseases Clinics of North America·Chad Deal
Nov 11, 2010·Annals of the New York Academy of Sciences·Aaron J WeissJeffrey I Mechanick
Jul 9, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hema KalyanaramanRenate B Pilz
Oct 20, 2011·The Annals of Pharmacotherapy·Robert D Beckett, Amy Heck Sheehan
Sep 5, 2014·Endocrinology·Jisha JoshuaRenate B Pilz
Aug 30, 2020·Annals of the New York Academy of Sciences·Se-Min KimMone Zaidi
Mar 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Negar GolchinShelly L Gray
Dec 30, 2020·The Journal of Clinical Investigation·Zixue JinBrendan Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
S J WimalawansaDonald R Hoover
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
S A JamalS R Cummings
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Lars RejnmarkLeif Mosekilde
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
S A JamalGillian A Hawker
© 2021 Meta ULC. All rights reserved