Use of Orlistat 60 mg in the management of weight loss before bariatric surgery

The Annals of Pharmacotherapy
Margaret MaloneJennifer Lindstrom

Abstract

Patients undergoing gastric bypass surgery are usually required to lose weight during the preoperative phase of their management. For some individuals, this is difficult to achieve with diet and exercise alone, and the use of weight loss medication may be considered a treatment option. To evaluate the use of orlistat 60 mg taken up to 3 times daily as an adjunct to achieve the 10% preoperative weight loss recommended in this bariatric program prior to gastric bypass surgery. The aim was to recruit 50 patients (25 treatment, 25 controls) who were in the preoperative phase of their bariatric program. Patients were referred by their physician. Control subjects were selected from individuals who were eligible but not interested in participating in the study during the same period. All patients received usual care. Nineteen patients (5 males) and 19 age- and sex-matched controls were included. The mean (SD) initial body mass index for the treatment versus control group was, respectively, 49.5 (10.5) versus 47.2 (4.9) kg/m(2) (p = 0.559). At 3 months, the percent excess weight (EW) loss was 2.4 (3.8) (n = 15) versus 5.5 (7.6) (n = 19) (p = 0.111) and the percent total body weight (TBW) loss was 1.2 (1.9) versus 2.9 (4.1) (p = 0.103)....Continue Reading

References

Feb 3, 2005·Obesity Research·Thomas A WaddenKirstin J Byrne
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Oct 2, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Ronald K EvansJames W Maher
May 9, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickUNKNOWN American Society for Metabolic & Bariatric Surgery
May 21, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·UNKNOWN Allied Health Sciences Section Ad Hoc Nutrition CommitteeJulie Parrott
Jan 31, 2009·Obesity·Thomas A WaddenUNKNOWN Look AHEAD Research Group
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Jan 27, 2010·Archives of Internal Medicine·William S YancyEugene Z Oddone
Jul 23, 2011·Obesity·Thomas A WaddenUNKNOWN Look AHEAD Research Group

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Methods Mentioned

BETA
gastric bypass

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