PMID: 6974710Jan 1, 1981Paper

Use of Orthoclone monoclonal antibodies in the study of selected dermatologic conditions

International Journal of Immunopharmacology
C L BergerR L Edelson

Abstract

Monoclonal antibodies recognizing human T cell differentiation antigens were used to study lymphocyte populations in three cutaneous diseases. Neoplastic lymphocytes from patients with varying phases of cutaneous T cell lymphoma (mycosis fungoides, Sezary syndrome and related presentations) were reactive with OKT1 and OKT3 (pan T cell reagents) and OKT4 (an antibody defining the functional "helper" T cell subset). The malignant cells lacked membrane antigens reactive with OKT5 and OKT8 (markers of "suppressor" T cells). The presence of an OKT1+, OKT3+, OKT4+, OKT5-, OKT8- phenotype on the neoplastic T lymphocytes of cutaneous T cell lymphoma (CTCL) supports the clinical impression that all phases of CTCL represent a single disease entity. A patient with pemphigus vulgaris, a disease of autoreactive, antiepidermal antibodies was shown to consistently have a marked expansion of the peripheral blood OKT4 reactive T lymphocyte population. These findings suggest that autoantibodies in pemphigus vulgaris may occur in the context of a profound OKT4/OKT5 immunoregulatory imbalance. Peripheral blood lymphocytes from patients ith extensive psoriasis vulgaris had a normal profile of reactivity with the OKT antibodies. In addition, OKT6 (m...Continue Reading

References

Dec 1, 1979·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S A SchwartzY S Choi
Jul 1, 1978·The British Journal of Dermatology·G Kavli
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C D PlatsoucasS Gupta
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Jul 21, 1977·Nature·G RowdenA K Sullivan
Jun 1, 1978·Clinical and Experimental Dermatology·B SafaiR A Good
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E FithianR Edelson
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Sep 1, 1980·Vox Sanguinis·P C Kung, G Goldstein
Nov 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·E H BEUTNER, R E JORDON

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Citations

Jul 1, 1983·Journal of Clinical Immunology·A R AhmedA S Saxon
Jan 1, 1981·Leukemia Research·M F GreavesG Goldstein
Jul 1, 1988·Clinical Microbiology Reviews·W J PayneW J Martin

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