PMID: 696786Sep 1, 1978Paper

Use of partial exchange transfusion preoperatively in patients with sickle cell hemoglobinopathies

American Journal of Obstetrics and Gynecology
J C MorrisonE T Bucovaz

Abstract

Sickle cell anemia and other severe sickle cell disorders (hemoglobin SC and hemoglobin S-thalassemia) are known to complicate surgical procedures in susceptible patients. Although transfusions have been used preoperatively to increase the packed cell volume, we have recently used the method of partial exchange transfusion in the treatment of patients with these disorders in the preoperative period. Forty-two patients with significant sickle cell hemoglobinopathies underwent operative procedures on various surgical services. The goal was to obtain a hemoglobin A percentage of 40 or above in each case, and this required 480 to 1,150 c.c. of buffy coat poor washed red cells (mean 820 c.c.). The number of complications in the intraoperative and postoperative period in this study was compared to those found in the literature. There was a significant decrease in morbidity and mortality rates noted with the use of these transfusions. There appeared to be a great advantage on a cost-benefit ratio, as well as an improvement in the physiologic state of the patient. Although the results of this study show significant improvement over previous investigations, there are many facets unknown concerning the use of this modality under these an...Continue Reading

Citations

Apr 15, 2000·Journal of Clinical Apheresis·K M Grima
Sep 19, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Maryam A Al KahtaniNaji Aljohani
Jan 1, 1993·Journal of Clinical Apheresis·B C McLeodH G Klein
Mar 10, 2009·Archives of Gynecology and Obstetrics·Fathia E Al JamaMohammad Sayedur Rahman
Aug 29, 2019·American Journal of Hematology·Frederica SchyrrRaffaele Renella
Mar 12, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Constance F M Danielson
Nov 1, 1993·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·J B Thornton, D R Sams
Dec 1, 1979·AORN Journal·V G Miller
Sep 1, 1994·American Journal of Surgery·C E Scott-Conner, C D Brunson

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