Use of PCA3 in detecting prostate cancer in initial and repeat prostate biopsy patients

The Prostate
Roland R GoodeK Kent Chevli

Abstract

The PCA3 urinary assay has shown promise in predicting the presence of prostate cancer. We evaluated the value of this test in patients undergoing initial and repeat prostate biopsy. PCA3 and PSA levels were obtained from 456 men with no known personal history of prostate cancer prior to prostate biopsy. Two hundred eighty-nine men underwent an initial prostate biopsy and 167 underwent a repeat prostate biopsy. PCA3 and PSA levels were compared to the prostate biopsy results. PCA3 score was shown to be independent of prostate volume (P = 0.162) and PSA level (P = 0.959). PCA3 scores were significantly higher in patients with cancer on prostate biopsy compared to patients with negative biopsy results (P < 0.0001). In logistic regression, PCA3 showed a significantly higher AUC than PSA (0.726 vs. 0.512, P = 0.0001). This difference persisted when examining the initial biopsy subgroup, with PCA3 out-performing PSA (AUC 0.772 vs. AUC = 0.552, P < 0.0001), but not in the repeat biopsy subgroup (AUC = 0.605 vs. AUC = 0.500, P = 0.2488). PCA3 was found to be a better predictor of prostate cancer than PSA in the total population as well as the initial biopsy population, but was not superior to PSA in the repeat biopsy population. Prost...Continue Reading

References

Apr 1, 1987·The Journal of Urology·P GuinanP Ray
Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Dec 1, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter S Bunting
Jun 20, 2003·European Urology·Daphne HesselsJack A Schalken
Jul 6, 2004·Clinical Biochemistry·Stephen D MikolajczykHarry G Rittenhouse
Aug 11, 2004·Urology·Yves FradetCamille Chypre
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Kelly A LandersRobert A Gardiner
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martijn P M Q van GilsJack A Schalken
Feb 26, 2008·The Journal of Urology·Ina L DerasJack Groskopf
Jul 8, 2008·European Urology·Alexander HaeseJack A Schalken
Oct 18, 2008·Clinical Chemistry·Girish SardanaEleftherios P Diamandis
Jan 13, 2010·Nature Reviews. Urology·Guillaume Ploussard, Alexandre de la Taille
May 8, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lori J SokollDaniel W Chan
Feb 22, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Atsushi OchiaiZephyr Fors
Feb 22, 2011·The Journal of Urology·Virginie Vlaeminck-GuillemAlain Ruffion
Apr 19, 2011·The Journal of Urology·Alexandre de la TailleAlexander Haese

❮ Previous
Next ❯

Citations

Jul 25, 2013·International Journal of Molecular Sciences·Natalia CerneiVojtech Adam
Sep 3, 2013·International Journal of Molecular Sciences·Alain RuffionVirginie Vlaeminck-Guillem
May 8, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Laura FojXavier Filella
Nov 29, 2015·The Urologic Clinics of North America·Jeffrey J TosoianChristian P Pavlovich
Sep 12, 2015·Future Oncology·Carsten StephanBernhard Ralla
Feb 6, 2015·Journal of Experimental & Clinical Cancer Research : CR·Roberta MerolaLaura Conti
Sep 13, 2015·BMC Cancer·Jose Rubio-BrionesJose A Lopez-Guerrero
May 28, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bin HuHongwei Yang
Apr 15, 2014·Biochimica Et Biophysica Acta·Carsten StephanKlaus Jung
Nov 26, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ettore CapoluongoMario Plebani
Jan 22, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Zhiqiang QinRuipeng Jia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.