Use of pentoxifylline and tocopherol in the management of osteoradionecrosis

The British Journal of Oral & Maxillofacial Surgery
Vinod PatelMark McGurk

Abstract

Osteoradionecrosis (ORN) is a complication of radiotherapy, and is difficult to manage once established. However, its pathogenesis has been reinvestigated, and it is now thought to be potentially amenable to treatment with pentoxifylline and tocopherol (vitamin E). We made a retrospective analysis of 62 patients with established ORN who were treated in this way. When only pentoxifylline and vitamin E was used ORN resolved in 14/25 (56%) but paradoxically, when it was combined with antibiotics, only 6/22 resolved (27%). The next stage would ideally be to incorporate the treatment in a randomised clinical trial against both standard antibiotic treatment and hyperbaric oxygen.

References

Feb 1, 1987·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J B EpsteinP Stevenson-Moore
Jan 1, 1994·International Journal of Radiation Biology·P A Riley
Jun 1, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M M Curi, L L Dib
Jul 1, 1997·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J K WongM McLean
Jun 28, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sylvie DelanianJean-Louis Lefaix
Nov 16, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sylvie Delanian, Jean-Louis Lefaix
May 19, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean-Pierre PignonUNKNOWN MACH-NC Collaborative Group
Oct 31, 2009·The Lancet Oncology·Jeffrey S TobiasUNKNOWN UK Head and Neck Cancer Trialists' Group
Dec 1, 2010·International Journal of Oral and Maxillofacial Surgery·S Nabil, N Samman
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Syed Nabil, Nabil Samman
Jul 6, 2014·European Annals of Otorhinolaryngology, Head and Neck Diseases·L RobardS Delanian

❮ Previous
Next ❯

Citations

Sep 16, 2016·The British Journal of Oral & Maxillofacial Surgery·Aidan Graham
Feb 12, 2017·British Dental Journal·V PatelM McGurk
Jan 6, 2018·The Journal of Craniofacial Surgery·Hélder Antônio Rebelo PontesJoão Mateus Mendes Cerqueira
Nov 21, 2019·The Laryngoscope·Alexis DissardNicolas Saroul
Aug 3, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Benjamin D LovinMarc-Elie Nader
Jan 2, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sagar PatelVinod Patel
Oct 28, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Raíssa Soares Dos AnjosIgor Henrique Morais Silva
Jan 8, 2021·International Journal of Radiation Oncology, Biology, Physics·Andrew J FrankartVinita Takiar
Dec 29, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jordan GigliottiAnthony B Morlandt
May 15, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·D C R Fernandes, H J N Andreyev

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Medical and Pediatric Oncology
H L AshamallaP Winkler
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Jacques Bessereau, Djillali Annane
The British Journal of Oral & Maxillofacial Surgery
H C Schwartz
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Jiong Lü, Fei-Yun Ping
© 2022 Meta ULC. All rights reserved