Use of pentoxifylline in assisted reproductive technology

Human Reproduction
H TournayeA C Van Steirteghem

Abstract

Methods for improving the fertilizing potential of the spermatozoa in human in-vitro fertilization (IVF) include the stimulation of sperm function in vitro. Metabolic stimulation in vitro has become a major issue in assisted reproductive technology (ART). Here, we review our research on the unselective use of pentoxifylline in IVF for male-factor infertility. Data from our controlled studies indicate that an indiscriminate use of 3.6 mM pentoxifylline, alone or in combination with 3.0 mM 2-deoxyadenosine, is not beneficial in enhancing fertilization rates in zero and poor in-vitro fertilizers or in the presence of antisperm antibodies. An assessment of the effects of pentoxifylline on sperm function prior to IVF may ensure a more rational use of these compounds in selected cases undergoing ART. At present, however, controlled studies in subgroups of patients selected by functional testing are still lacking.

Citations

Jan 6, 2011·Der Urologe. Ausg. A·M TrottmannA J Becker
Feb 4, 2006·Reproductive Biomedicine Online·Jean-François GriveauDominique Le Lannou
Dec 19, 2007·Asian Journal of Andrology·F DimitriadisN Sofikitis
Nov 18, 2003·Reproductive Biology and Endocrinology : RB&E·Ralf R Henkel, Wolf-Bernhard Schill
Apr 12, 2013·Human Reproduction Update·David MortimerCharles H Muller
Nov 15, 2007·Reproductive Sciences·Scott E EdwardsCarmen J Williams

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