PMID: 7011223Mar 1, 1981Paper

Use of peroperative cefoxitin to prevent infection after colonic and rectal surgery

Annals of Surgery
C E HoffmannJ M Watts


A double-blind, controlled trial was performed to assess the effect of a short intraoperative course of Cefoxitin, a new broad spectrum cephamycin antibiotic, on the incidence of septic complications following elective colonic and rectal surgery. In addition to a two-day preoperative bowel preparation, patients entered in the study received a short course of either Cefoxitin (three 2g intravenous bolus doses at two-hour intervals, the first before skin incision) or a matching placebo. Thirty-two patients received Cefoxitin and 33 patients received the placebo. Postoperative abdominal wound infections developed in one (3%) of the Cefoxitin-treated patients and nine (27%) of the placebo-treated patients. This difference is statistically significant (p = 0.01). Septic complications remote from the abdominal wound, e.g. intra-abdominal abscesses, occurred in both Cefoxitin-treated and placebo-treated patients, but numbers were too small for meaningful analysis. The study shows that even a very short peroperative course of Cefoxitin is highly effective in reducing postoperative abdominal wound infections after elective colorectal surgery.


Jul 2, 1977·Lancet·R S FeathersP Noone
Jul 1, 1978·The Journal of Antimicrobial Chemotherapy·C van Winzum
Jul 1, 1976·The British Journal of Surgery·M R KeighleyJ Alexander-Williams
Jul 1, 1977·Diseases of the Colon and Rectum·R DowningM R Keighley
Sep 1, 1969·The British Journal of Surgery·M T EverettJ Nettleton


Oct 13, 2001·Diseases of the Colon and Rectum·O ZmoraS D Wexner
Mar 1, 1986·Diseases of the Colon and Rectum·M N de la Hunt, S J Karran
Feb 17, 2009·Surgical Infections·Donald E Fry
Mar 7, 2013·Surgical Infections·Dale W BratzlerSociety for Healthcare Epidemiology of America (SHEA)
Nov 20, 2008·Techniques in Coloproctology·A F J de BruinE van der Harst
Jan 1, 1997·AORN Journal·J D Butts, E T Wolford
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
Feb 27, 2010·Journal of Biomedical Materials Research. Part a·Guruprakash SubbiahdossRoel Kuijer
Sep 1, 1988·The Australian and New Zealand Journal of Surgery·J C HallS M Gibb
Oct 1, 1990·Hospital Practice·I Brook
Sep 1, 1984·Pharmacotherapy·T G Burnakis
Feb 1, 1990·Diseases of the Colon and Rectum·J A Solla, D A Rothenberger
Mar 1, 1985·Drug Intelligence & Clinical Pharmacy·R P Rapp, D Blue

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.