PMID: 7011223Mar 1, 1981Paper

Use of peroperative cefoxitin to prevent infection after colonic and rectal surgery

Annals of Surgery
C E HoffmannJ M Watts

Abstract

A double-blind, controlled trial was performed to assess the effect of a short intraoperative course of Cefoxitin, a new broad spectrum cephamycin antibiotic, on the incidence of septic complications following elective colonic and rectal surgery. In addition to a two-day preoperative bowel preparation, patients entered in the study received a short course of either Cefoxitin (three 2g intravenous bolus doses at two-hour intervals, the first before skin incision) or a matching placebo. Thirty-two patients received Cefoxitin and 33 patients received the placebo. Postoperative abdominal wound infections developed in one (3%) of the Cefoxitin-treated patients and nine (27%) of the placebo-treated patients. This difference is statistically significant (p = 0.01). Septic complications remote from the abdominal wound, e.g. intra-abdominal abscesses, occurred in both Cefoxitin-treated and placebo-treated patients, but numbers were too small for meaningful analysis. The study shows that even a very short peroperative course of Cefoxitin is highly effective in reducing postoperative abdominal wound infections after elective colorectal surgery.

References

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Citations

Oct 13, 2001·Diseases of the Colon and Rectum·O ZmoraS D Wexner
Mar 1, 1986·Diseases of the Colon and Rectum·M N de la Hunt, S J Karran
Feb 17, 2009·Surgical Infections·Donald E Fry
Mar 7, 2013·Surgical Infections·Dale W BratzlerSociety for Healthcare Epidemiology of America (SHEA)
Nov 20, 2008·Techniques in Coloproctology·A F J de BruinE van der Harst
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Sep 1, 1984·Pharmacotherapy·T G Burnakis
Feb 1, 1990·Diseases of the Colon and Rectum·J A Solla, D A Rothenberger
Mar 1, 1985·Drug Intelligence & Clinical Pharmacy·R P Rapp, D Blue

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