Use of personalized medicine in the selection of patients for renal transplantation: views of Quebec transplant physicians and referring nephrologists

Personalized Medicine
Marianne Dion-LabrieHubert Doucet

Abstract

To explore the views of physicians on the use of personalized medicine tools to develop a new method for selecting potential recipients of a renal allograft. A total of 22 semidirected interviews, using clinical case studies. According to the participants, this method has several possible applications within renal transplantation (individualizing immunosuppressive therapy, help with decision making, and possibly with the selection of patients). It could be more effective than the method presently used. The method must be validated scientifically, and must also involve clinical judgment. The use of personalized medicine within transplantation must be in the best interests of the patient. An ethical reflection is necessary in order to focus on the possibility of patients being excluded, as well as on the resolution of the equity/efficacy dilemma. Empirical research has shown itself to be essential for ascertaining the views of the clinicians who will be working with the tools provided by personalized medicine.

References

Jan 1, 1995·Social Work in Health Care·P A FrazierK E Dahl
Jan 5, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alain Vandewalle
Apr 29, 2004·Journal of Proteome Research·Svetlana BorozdenkovaMarlene L Rose
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elaine S Mansfield, Minnie M Sarwal
Nov 1, 2005·Journal of the American College of Cardiology·Geoffrey S GinsburgL Kristin Newby
Nov 9, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Greg KnollUNKNOWN Kidney Transplant Working Group of the Canadian Society of Transplantation
Jan 5, 2006·European Journal of Human Genetics : EJHG·David Gurwitz, Gregory Livshits
Feb 17, 2006·Current Opinion in Nephrology and Hypertension·Holger SchmidMatthias Kretzler
Jun 6, 2006·Current Opinion in Pharmacology·Roshan Agarwal, Stan B Kaye
Jun 17, 2006·Health & Social Work·Maurice S Fisher
Jul 25, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sahar BayatMichèle Kessler
Oct 24, 2006·Pharmacogenomics·Jan van der GreefRobert N McBurney
Dec 16, 2006·Current Drug Targets·Norbert W Paul, Heiner Fangerau
Mar 24, 2007·PLoS Medicine·Chantal BaronClaude Perreault
Apr 4, 2007·Trends in Molecular Medicine·Tarik F Massoud, Sanjiv S Gambhir
May 4, 2007·The Journal of Clinical Investigation·Marc L Reitman, Eric E Schadt
Aug 24, 2007·Expert Opinion on Pharmacotherapy·Fu Liang NgIain A M MacPhee
Sep 12, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D A MandelbrotJ R Rodrigue
Oct 11, 2007·JAMA : the Journal of the American Medical Association·Wylie Burke, Bruce M Psaty
Mar 12, 2008·Archives of Ophthalmology·Janey L Wiggs
May 15, 2008·Journal of General Internal Medicine·Cheryl R ClarkJohn Z Ayanian
May 31, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D CattaneoN Perico
Dec 9, 2008·Nephron. Clinical Practice·Aisling E Courtney, Alexander P Maxwell
Jan 1, 2009·Personalized Medicine·Fintan R Steele
Aug 1, 2006·Personalized Medicine·David H GehoLance Liotta

❮ Previous
Next ❯

Citations

Nov 23, 2019·Pharmacogenomics·Kimberly M DeiningerChristina L Aquilante
Apr 2, 2020·Canadian Journal of Kidney Health and Disease·Timothy CaulfieldPaul Keown

❮ Previous
Next ❯

Software Mentioned

QSR N Vivo

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved