Use of phenotypic covariates in association analysis by sequential addition of cases

European Journal of Human Genetics : EJHG
Stuart MacgregorPeter A Holmans

Abstract

Optimal use of phenotype information is important in complex disease gene mapping. We describe a method, sequential addition, for the analysis of case-control data by taking into account of a quantitative trait that is measured in cases but not in controls. The method also provides an estimate of the best phenotype definition for future studies. We demonstrate proof of principle, using an example of incorporation of age-at-onset data into a study of a small sample for association between APOE and late-onset Alzheimer's disease. The sequential addition method finds evidence of association when conventional case-control methods fail. We also illustrate the use of the method for taking account of a dimensional measure of psychosis in a study of the schizophrenia susceptibility gene, dysbindin, in bipolar disorder.

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Citations

Sep 12, 2008·Human Genetics·Emmanuelle GéninFrançoise Clerget-Darpoux
Jul 9, 2008·Journal of Neural Transmission·C K ThoeringerA Erhardt
Apr 1, 2010·European Journal of Human Genetics : EJHG·Sarah E BergenKenneth S Kendler
Nov 11, 2011·The Journal of Allergy and Clinical Immunology·María Pino-YanesCarlos Flores
Jan 9, 2008·Biological Psychiatry·Xiangning ChenKenneth S Kendler
Jan 13, 2009·Bipolar Disorders·Liz FortyNick Craddock
May 14, 2008·Genetic Epidemiology·Ren-Hua ChungElizabeth R Hauser
Jun 24, 2009·Genetic Epidemiology·Hervé PerdryFrançoise Clerget-Darpoux
Aug 24, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robert A PowerCathryn M Lewis
Jun 23, 2010·Genetic Epidemiology·Xuejun QinSilke Schmidt
Oct 7, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·A H FanousB P Riley
Sep 18, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sarah E BergenKenneth S Kendler

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