Use of phosphonoformic acid to induce phosphaturia in chronic renal failure in rats

Renal Failure
M Loghman-Adham, G T Motock

Abstract

In chronic renal failure (CRF), phosphate (Pi) retention may lead to secondary hyperparathyroidism and progression to end-stage renal disease (ESRD). Dietary phosphorus restriction or phosphate binders can slow progression in experimental CRF. Conversely, diets high in phosphorus can accelerate the progression toward ESRD. Phosphate binders reduce intestinal Pi absorption but have no effect on its renal excretion. Phosphonoformic acid (PFA, foscarnet) is a specific inhibitor of both intestinal and renal brush border Na(+)-Pi cotransport. It causes phosphaturia when administered parenterally or orally to rats. To determine the effect of oral PFA on renal function and on phosphate excretion in renal insufficiency, PFA was administered in drinking water to rats with CRF produced by 5/6th nephrectomy. Blood and 24-h urine collections were performed every 2 weeks for determination of plasma Pi and creatinine concentrations, urinary protein excretion, and urinary creatinine and Pi clearances. PFA, administered for 8 weeks, did not exert any adverse effects on any of the measured parameters. The slopes of the reciprocal of plasma creatinine versus time were not different between control and PFA-treated rats. Although PFA increased Pi ...Continue Reading

References

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Citations

Apr 16, 2002·Current Opinion in Pharmacology·Richard M Edwards
Dec 4, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Mahmoud Loghman-Adham
May 14, 2011·Journal of Pharmaceutical Sciences·Ken-ichi MiyamotoHiroko Segawa
Apr 26, 2007·Kidney International·J MarksUNKNOWN Epithelial Transport and Cell Biology Group
Feb 6, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Grace J Lee, Joanne Marks
Jun 11, 2010·American Journal of Physiology. Renal Physiology·Joanne MarksRobert J Unwin
Jun 7, 2019·Nature Reviews. Nephrology·Moshe LeviHeini Murer
Aug 4, 2020·American Journal of Physiology. Renal Physiology·Linto ThomasTimo Rieg
Dec 12, 2018·Pflügers Archiv : European journal of physiology·Víctor SorribasCecilia Sosa

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