Use of plasma clearance of iohexol for estimating glomerular filtration rate in cats

American Journal of Veterinary Research
K Miyamoto

Abstract

To determine whether plasma clearance of iohexol (PCio) can be used to estimate glomerular filtration rate (GFR) in cats. 4 renal-intact and 6 partially nephrectomized adult cats. Plasma clearance of iohexol was determined after IV administration of iohexol; plasma concentrations of iodine were measured by use of a colorimetric assay. Results for PCio were compared with simultaneously obtained values for urinary clearance of creatinine (CCr). The colorimetric assay used to measure plasma iodine concentrations was extremely precise. Results of PCio for all cats, renal-intact cats, and partially nephrectomized cats were closely associated with results of CCr. Mean difference between CCr and PCio determined for all cats was 0.95 ml/min/kg, which was < 30% of mean CCr for renal-intact cats. Coefficients of variance for PCio (5%) and CCr (8%) in renal-intact cats were similar. Plasma clearance of iohexol determined by use of a simple colorimetric assay provided an estimation of GFR in cats that was not significantly different from that provided by CCr. Moreover, PCio more reliably estimates renal function than BUN and plasma creatinine concentrations. Because determination of PCio is less labor intensive and invasive, compared with ...Continue Reading

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Citations

Oct 20, 2006·Journal of Feline Medicine and Surgery·Alain Le GarreresHervé P Lefebvre
Apr 23, 2010·The Journal of Veterinary Medical Science·Yuichi MiyagawaHisashi Hirose
Dec 16, 2003·American Journal of Veterinary Research·Kathleen C GondaW Emmett Braselton
Jul 2, 2009·American Journal of Veterinary Research·Laura A GoodmanSteven C Budsberg
Dec 1, 2011·American Journal of Veterinary Research·Natalie C FinchReidun Heiene
Oct 23, 2013·The Veterinary Clinics of North America. Small Animal Practice·Barrak M Pressler
Jun 15, 2010·The Veterinary Journal·Vanessa E Von Hendy-Willson, Barrak M Pressler
Mar 24, 2006·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Kristen J O'Dell-AndersonPeter D Constable
Mar 24, 2006·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Isabelle Goy-ThollotPaul Y Barthez
May 8, 2013·Journal of Veterinary Internal Medicine·N C FinchA M Peters
Dec 21, 2011·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·L Abbigail GrangerKate Alexander
Aug 25, 2015·Clinics in Laboratory Medicine·Barrak M Pressler
Aug 27, 2015·American Journal of Veterinary Research·Yui SasakiKazuhisa Furuhama
Mar 6, 2002·Journal of Feline Medicine and Surgery·K Miyamoto
Aug 7, 2007·The Journal of Veterinary Medical Science·Miori KishimotoYoh-Ichi Miyake
Aug 25, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Toralf MelsomBjørn O Eriksen
Aug 3, 2019·Journal of Veterinary Internal Medicine·Myles McKennaRosanne Jepson
Jul 8, 2014·The Journal of Veterinary Medical Science·Ryosuke IwamaHiroshi Satoh
Jun 6, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Natalie EbertElke Schaeffner
Jun 5, 2008·Pediatric Blood & Cancer·Marika H GrönroosToivo T Salmi
Nov 8, 2014·Pediatric Transplantation·Manjula GowrishankarAmbikaipakan Senthilselvan
Nov 13, 2020·The Journal of Veterinary Medical Science·Yuichi MiyagawaNaoyuki Takemura

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